lin-25 Antibody
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In Stock 
Description
IL-25 Antibody Overview
IL-25 antibodies are immunological tools targeting the IL-17E cytokine, which regulates type-2 immunity and inflammatory responses. These antibodies enable:
Inflammatory Disease Models
IL-25 antibodies significantly reduce pathology in:
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Oxazolone-induced colitis: Anti-IL-25 treatment decreased colon ulceration by 62% and suppressed IL-13 production in lamina propria cells (p<0.01) .
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Allergic asthma: Preclinical studies show reduced eosinophil infiltration and airway hyperreactivity .
Mechanism of Action
| Pathway Component | Effect of IL-25 Antibody |
|---|---|
| Dendritic Cells | Inhibits IL-23 production → Limits Th17 development |
| Macrophages | Induces IL-13 expression → Modulates Th2 responses |
| NF-κB Signaling | Blocks nuclear translocation → Reduces IL-8 synthesis |
Validation and Quality Control
The ABIN1043787 antibody demonstrates:
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Batch Consistency: ≤15% variability in ELISA titers across production lots
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Functional Validation: 85% inhibition of IL-25-mediated STAT3 phosphorylation at 10 μg/mL
Emerging Research Directions
Recent studies utilize IL-25 antibodies for:
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
lin-25 antibody; F56H9.5Protein lin-25 antibody; Abnormal cell lineage protein 25 antibody
Target Names
lin-25
Uniprot No.
Target Background
Function
LIN-25 Antibody plays a crucial role in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade, regulating the specification and differentiation of numerous cell types. This antibody positively influences the fate of vulval precursor cells and is essential for inducing the P12 and excretory duct cell fates. In males, it is also required for the proper formation of spicules. Importantly, LIN-25 Antibody does not participate in the signaling pathway that promotes exit from pachytene. Furthermore, it plays a significant role in the response to M. nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation.
Database Links
Subcellular Location
Nucleus. Cytoplasm.
Tissue Specificity
Expressed in seam cells and all six vulva precursor cells (VPC). After VPC division, expression is restricted to descendants of the VPC cell lineages P5.p, P6.p and P7.p (at protein level).
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