lin-36 Antibody

LIN-36 Protein in C. elegans: A Cell-Cycle Regulator

LIN-36 is a C. elegans THAP domain protein critical for cell-cycle regulation and germline development. It functions as part of the DREAM (DP, E2F, and MuvB) complex, which represses cell-cycle genes and maintains quiescence. Key findings include:

Mechanistic Roles

LIN-36 and LIN-15B exhibit distinct genomic binding patterns:

• LIN-36: Overlaps with LIN-35 at 95% of peaks, enriched in cell-cycle genes.

• LIN-15B: Overlaps with LIN-35 at 72% of peaks, enriched in germline-specific genes.

L-35/L-36 Antigens in Human T Cells

In human immunology, monoclonal antibodies L-35 and L-36 define novel T cell activation antigens expressed on both CD4⁺ and CD8⁺ subsets. These markers are absent on resting T cells but appear after mitogen stimulation.

Antibodies Targeting IL-36 or Connexin 36

While no direct references to "LIN-36 antibodies" exist, antibodies against IL-36 family members or Connexin 36 are well-characterized:

IL-36 α/β/γ Antibodies

Connexin 36 Antibody

Epigenetic Markers: H3K36me3 Antibodies

Though unrelated to LIN-36, antibodies targeting histone modifications (e.g., H3K36me3) are clinically relevant. For example: