lin-41 Antibody

LIN-41 is a heterochronic protein acting downstream of let-7 in temporal developmental patterning. It plays a crucial role in regulating the timing of postembryonic hypodermal seam cell division, fusion events, and adult alae formation. Specifically, LIN-41 represses lin-29 during late larval stages, preventing premature terminal differentiation of hypodermal seam cells and promoting their continued division. This protein is involved in post-transcriptional gene regulation via two independent pathways: direct RNA binding and subsequent mRNA decay or translational repression, depending on the target site location (5'UTR or 3'UTR). Furthermore, LIN-41 degrades dmd-3 mRNA, controlling the timing and extent of male tail tip morphogenesis and contributing to sexual maturation of the nervous system.

Key Research Findings on LIN-41 Function:

1. LIN-41 represses translation of spn-4 and meg-1 during oocyte meiotic maturation and the oocyte-to-embryo transition. PMID: 28576864
2. LIN-41 silences mRNAs through two distinct mechanisms: translational repression or mRNA degradation, determined by the binding site location on the target mRNA. PMID: 28111013
3. LIN-41 regulates gene expression for timely centrosome elimination around the diplotene stage in female germ cells. PMID: 26764090
4. Regulation of LIN-41 alone is sufficient to prevent vulval rupturing, indicating let-7's role in directing vulval development through specific LIN-41 regulation. PMID: 25669883
5. LIN-41 functions differently in the germline and soma via distinct molecular mechanisms. PMID: 25167051
6. In older anterior ventral microtubule (AVM) axons, let-7 inhibits regeneration by down-regulating LIN-41, a key AVM axon regeneration-promoting factor. PMID: 23599497
7. NMR structure analysis reveals details of let-7 miRNA binding to lin-41 mRNA, involving a complex with non-canonical seed region elements. PMID: 20660479
8. lin-41, a vertebrate lin-41 homologue, functions as a heterochronic gene. PMID: 16477647
9. Gain-of-function lin-41 alleles suggest that small changes in LIN-41 could significantly impact male tail evolution; LIN-41 governs the timing and extent of male tail tip morphogenesis in a dose-dependent manner. PMID: 16806150
10. NMR solution structure analysis of a model mimicking the let-7 miRNA interaction with its complementary site in the 3' untranslated region of lin-41 mRNA. PMID: 18296482

KEGG: cel:CELE_C12C8.3

STRING: 6239.C12C8.3a.1

UniGene: Cel.5222