syd-2 Antibody
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Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
syd-2 antibody; F59F5.6Liprin-alpha antibody; LAR-interacting protein alpha antibody; Synapse defective protein 2 antibody
Target Names
syd-2
Uniprot No.
Target Background
Function
This antibody targets SYD-2, a protein implicated in regulating the structure of the neuronal active zone. The active zone is the presynaptic site from which synaptic vesicles release neurotransmitters. SYD-2's function may be associated with the liprin-β protein hlb-1.
Gene References Into Functions
SYD-2 Function and Related Studies:
- N-terminal coiled-coil (CC) domains: Essential for the synaptogenic activity of SYD-2. (PMID: 23541703)
- Regulation of density particle (DP) polymerization: A primary role of SYD-2/Liprin-α in synaptogenesis. (PMID: 24322429)
- DCV trafficking and polarized distribution: SYD-2 regulates the bidirectional mobility of dense-core vesicles (DCVs). (PMID: 23358451)
- Presynaptic specialization and synaptic vesicle accumulation: Loss-of-function mutations in C. elegans syd-2 alter presynaptic specialization size and disrupt synaptic vesicle accumulation. A coiled-coil domain missense mutation exhibits gain-of-function. (PMID: 17115037)
- Active zone assembly: SYD-2, along with SYD-1 and UNC-10, plays a critical role in presynaptic active zone assembly. (PMID: 19436057)
Database Links
Protein Families
Liprin family, Liprin-alpha subfamily
Subcellular Location
Cell junction, synapse. Note=Presynaptic region.
Tissue Specificity
Detected in vulval muscle and other cells near the vulva; in neurons located in the lateral ganglion, posterior ganglion, ventral cord and lateral body; and in pharyngeal and body wall muscle cells.
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