LECRK19 Antibody

The LECRK-I.9 protein is an essential receptor for extracellular ATP. It exhibits high-affinity ATP binding via its extracellular legume-lectin-like domain. This interaction is crucial for triggering intracellular calcium responses, activating mitogen-activated protein kinases 3 and 6 (MPK3 and MPK6), and initiating ATP-induced gene expression. LECRK-I.9 plays a multifaceted role in stress resistance and may participate in protein-protein interactions with RGD motif-containing proteins as potential ligands. It likely functions structurally and as a signaling molecule at the plant cell surface, contributing to the resistance response against the oomycete pathogens Phytophthora infestans and Phytophthora capsici.

• Phosphorylation site mutations within DORN1, a related receptor, abolish ATP-induced stomatal closure, highlighting the role of purinergic signaling via DORN1 in stomatal regulation. PMID: 29273780
• The involvement of LecRK-I.9 in the molecular mechanisms linking jasmonic acid signaling to cell wall damage and/or extracellular ATP perception is discussed. PMID: 27399963
• X-ray crystallographic analyses of the extracellular domain of DORN1 (the first identified plant ATP receptor) and its Camelina sativa ortholog have been reported. PMID: 27710944
• This review summarizes genetic and biochemical evidence supporting DORN1's role in extracellular ATP signaling, particularly within the context of plant stress responses. PMID: 25301072
• LecRK-I.9 insertion mutants exhibit increased susceptibility to Phytophthora, while overexpression enhances resistance. These findings strongly suggest a role for LecRK-I.9 in disease resistance via stabilization of the cell wall-plasma membrane continuum. PMID: 21483488
• DORN1 is essential for extracellular ATP perception and likely plays multiple roles in plant stress resistance. PMID: 24436418
• The lectin receptor kinase encoded by At5g60300 participates in protein-protein interactions with RGD-containing proteins, potentially acting as ligands, and may contribute to structural integrity and signaling at the plant cell surface. PMID: 16361528

KEGG: ath:AT5G60300

STRING: 3702.AT5G60300.3

UniGene: At.21114