LRPAP1 Antibody, FITC conjugated
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Description
Definition and Structure of LRPAP1 Antibody, FITC Conjugated
LRPAP1 Antibody targets the LRPAP1 protein, a chaperone involved in LDL receptor-related protein (LRP1) trafficking and implicated in autoimmune diseases and cancers like mantle cell lymphoma (MCL) . FITC conjugation (fluorescein isothiocyanate) enables fluorescent detection of LRPAP1 in cellular assays.
Table 1: Key Applications of LRPAP1 Antibodies
Mechanistic Insights from Studies
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Therapeutic Targeting:
Bispecific constructs (e.g., anti-CD3/LRPAP1) and IgG1-format BAR bodies use LRPAP1 to redirect T/NK cells against MCL cells . FITC-labeled antibodies could track these constructs’ binding efficiency. -
Viral Immune Evasion:
LRPAP1 binds IFNAR1 (interferon receptor), promoting its degradation and enhancing viral replication (e.g., EV71, HCoV-OC43) . FITC-conjugated antibodies confirmed extracellular LRPAP1’s role in IFNAR1 downregulation . -
Prognostic Value:
LRPAP1 autoantibodies (IgG/IgM) in MCL patients correlate with superior survival (5-year OS: 93% vs. 68% in seronegative patients) .
Technical Considerations
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Sensitivity: FITC conjugation requires optimization to avoid photobleaching during fluorescence assays .
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Cross-Reactivity: Validated in human, mouse, and rat models, but species-specific validation is recommended .
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Storage: Stable at -20°C; avoid repeated freeze-thaw cycles .
Future Directions
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. Delivery times may vary depending on your location and chosen shipping method. Please consult your local distributor for specific delivery estimates.
Synonyms
39 kDa receptor-associated protein antibody; A2MRAP antibody; A2RAP antibody; Alpha 2 macroglobulin receptor associated protein antibody; Alpha 2 MRAP antibody; Alpha-2-macroglobulin receptor-associated protein antibody; Alpha-2-MRAP antibody; AMRP_HUMAN antibody; HBP44 antibody; Lipoprotein receptor associated protein antibody; Low density lipoprotein receptor related protein associated protein 1 antibody; Low density lipoprotein receptor-related protein-associated protein 1 antibody; Low density lipoprotein related protein associated protein 1 alpha 2 macroglobulin receptor associated protein antibody; Low density lipoprotein related protein associated protein 1 antibody; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1) antibody; Lrpap1 antibody; MGC138272 antibody; MRAP antibody; MYP23 antibody; RAP antibody
Target Names
Uniprot No.
Target Background
Function
LRPAP1 Antibody, FITC conjugated, is a molecular chaperone that assists in the proper folding and trafficking of LDL receptor-related proteins. It plays a critical role in regulating the ligand binding activity of these proteins throughout the secretory pathway.
Gene References Into Functions
- The clinical and biometric characteristics we describe in this report are consistent with LRPAP1-related high myopia. These findings should prompt consideration of genetic testing for mutations in the LRPAP1 gene. PMID: 26271838
- Inhibition caused by reagents that block Rap activation can be reversed by pharmacologically mobilizing intracellular calcium. However, inhibition caused by acrosome reaction inhibitors that prevent Rab3 binding to GTP is not reversible. PMID: 25159528
- The LRPAP1 I allelic variant may be considered a potential candidate gene for Parkinson's disease, particularly in patients carrying the APOE epsilon4 allelic variant. PMID: 24504617
- RAP effectively inhibits light chain (LC) endocytosis by approximately 88% and alleviates LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells. PMID: 23894629
- Mutations in the LRPAP1 gene are associated with severe myopia in humans. PMID: 23830514
- LRP1-C/T, A2M-Ile/Val, and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with Alzheimer's disease. PMID: 20637261
- Research indicates that RAP is a novel Abeta-binding protein that facilitates cellular internalization of Abeta. PMID: 19826010
- Adenoviral-mediated expression of human receptor-associated protein RAP in a murine model of von Willebrand disease results in a sustained increase in FVIII over a period of 6 days. PMID: 11992244
- RAP is structurally organized into three domains located in the first third (1D), middle third (2D), and last third (3D) of the protein. All three domains exhibit stable tertiary structure when isolated and function as monomers. PMID: 14674767
- NMR structure of domain 1 of receptor-associated protein PMID: 15213425
- An insertion allele has been found to be associated with gallstone disease. PMID: 16704534
- RAP expression by thyrocytes is TSH-dependent, both in cultured thyroid cells and in vivo. PMID: 17123336
- Analysis of the relationship between ACE and LRPAP1 gene polymorphisms and age in an Italian population. PMID: 17536759
- The low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not identified as a risk factor for gallstone disease in a Polish population. PMID: 17913606
- The low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism is associated with gallstone disease and gallbladder carcinoma. PMID: 17987404
- LRP-1/LDLR-mediated uptake of A beta leads to degeneration of perivascular cells. PMID: 18055545
- Alterations in the RAP gene are not commonly observed as a cause of hypothyroidism. PMID: 18075286
- Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias. PMID: 18721259
Database Links
Involvement In Disease
Myopia 23, autosomal recessive (MYP23)
Protein Families
Alpha-2-MRAP family
Subcellular Location
Rough endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment lumen. Golgi apparatus, cis-Golgi network. Golgi apparatus lumen. Endosome lumen. Cell surface.
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