lst-4 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
lst-4 antibody; Y37A1B.2Sorting nexin lst-4 antibody; Lateral signaling target protein 4 antibody
Target Names
lst-4
Uniprot No.
Target Background
Function
LST-4 plays a crucial role in vulval development signaling by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Furthermore, it facilitates phagosomal membrane tubule formation, a critical process for phagosomal fusion with endosomes and lysosomes. LST-4 also recruits rab-7 to phagosomes through an interaction with dyn-1, contributing to phagosome maturation, an essential step in apoptotic cell corpse clearance. Notably, LST-4 binds phosphatidylinositol-3,4,5-trisphosphate.
Gene References Into Functions
- The functional conservation between LST-4 and SNX33 suggests that these early stages of apoptotic phagosome maturation are likely conserved across evolution. PMID: 21494661
- LST-4 and SNX-1 promote the extension of phagosomal tubules, facilitating the docking and fusion of intracellular vesicles. PMID: 21148288
Database Links
Protein Families
Sorting nexin family
Subcellular Location
Cytoplasm. Cytoplasmic vesicle, phagosome membrane.
Tissue Specificity
Expressed in vulval precursor cells (VPCs) and apoptotic germ cells. Colocalizes with actin, dyn-1 and rab-5 in early phagosomes.
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