luzp2 Antibody

Definition and Target

LUZP2 is a 346-amino-acid protein encoded by the LUZP2 gene located on chromosome 11p14.3 . The antibody targets this protein, which contains a leucine zipper motif facilitating protein-protein interactions, and is primarily expressed in the brain and pancreas . Its secretion and role in neuronal development suggest potential diagnostic and therapeutic applications .

Applications

The LUZP2 antibody is utilized in:

• Immunohistochemistry (IHC): Detects LUZP2 in tissues, including cerebral cortex and pancreas (Sigma-Aldrich HPA046161) .

• Western Blotting (WB): Validates protein expression in cancer cells (e.g., DU145 and PC3) .

• Enzyme-Linked Immunosorbent Assay (ELISA): Quantifies LUZP2 levels in biological fluids .

Prostate Cancer

• Drug Resistance: Overexpression of LUZP2 enhances resistance to paclitaxel in prostate cancer cells by upregulating RAD50, a DNA repair protein .

• Prognosis: High LUZP2 levels correlate with reduced immune infiltration and worse survival in castration-resistant prostate cancer (CRPC) .

Neurodevelopmental Disorders

• WAGR Syndrome: Deletions in LUZP2 are associated with Wilms tumor, aniridia, and genitourinary anomalies .

• Low-Grade Gliomas: Downregulation of LUZP2 predicts tumor progression and poor prognosis .

Mechanistic Insights

• Senescence Regulation: LUZP2 modulates cellular senescence via RNA/DNA methylation pathways .

• Immune Evasion: LUZP2 negatively correlates with 21 immune checkpoints in prostate cancer .

Clinical Relevance

• Therapeutic Target: LUZP2 inhibition sensitizes prostate cancer to chemotherapy .

• Biomarker: Elevated LUZP2 expression serves as a prognostic marker for aggressive PCa .