aex-3 Antibody

Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Liquid

14-16 weeks (made-to-order)

aex-3 antibody; C02H7.3MAP kinase-activating death domain protein antibody; Aboc antibody; expulsion defective protein 3 antibody; Regulator of presynaptic activity aex-3 antibody

aex-3

O02626

AEX-3 antibody targets a guanyl-nucleotide exchange factor that regulates small GTPases. Specifically, it catalyzes the conversion of the inactive, GDP-bound forms of Rab-3 and Cab-1 into their active, GTP-bound states. AEX-3 plays a crucial role in regulating presynaptic activity, interacting with Rab-3 to modulate synaptic vesicle release and also regulating the Cab-1 synaptic transmission pathway. It likely facilitates the recruitment of endophilin UNC-57 to synaptic vesicles by converting Rab-3 to its active GTP-bound form. Furthermore, through Rab-3 activation and subsequent regulation of dense-core vesicle trafficking, AEX-3 contributes to AVG neuron-mediated formation of the ventral nerve cord's right axon tract. AEX-3 also regulates anterior body muscle contractions (aBOC) and the expulsion phases of the defecation motor program (DMP). Its role in DMP regulation appears essential for intestinal cell fatty acid uptake.

KEGG: cel:CELE_C02H7.3

STRING: 6239.C02H7.3a

UniGene: Cel.18148

MADD family

Cell membrane. Cytoplasm.

Expressed in nearly all neurons.