Function
Mab21l2 is essential for various aspects of embryonic development. Its roles include the normal development of the eye, notochord, neural tube, and other organ systems; it is also crucial for embryonic turning.
Gene References Into Functions
- In mouse embryos, Mab21l2 exhibits strong expression in the developing eye, pharyngeal arches, and limb buds. (PMID: 24906020)
- Mab21l2 plays a critical role in both heart and liver development via septum transversum mesenchyme (STM) formation. (PMID: 22412967)
- Mab21l2 is required during embryonic development for processes such as embryonic turning, notochord formation, neural tube formation, and the development of other organ tissues. (PMID: 11857508)
- Studies indicate that Mab21l2 has crucial roles in retina development and ventral body wall formation. (PMID: 15385160)
Protein Families
Mab-21 family
Subcellular Location
Nucleus. Cytoplasm.
Tissue Specificity
Expressed in the adult cerebellum and eye, with lower levels in the adult forebrain. In embryos at 10.5 days post-coitum strongly expressed in the rostral and distal regions of the developing neural retina, with no expression immediately adjacent to the c