Customize mbr-1 Antibody

Description

Table 1: Biochemical Properties of the MBr1 Antigen

Property	Detail
Epitope Type	Carbohydrate (globo-series glycosphingolipid)
Key Sequence	Fucα1-2Galβ1-3GalNAcβ1-3Gal
Tissue Distribution	Normal mammary epithelium; carcinomas of breast, ovary, lung, prostate
Diagnostic Utility	Detects micrometastases in bone marrow and lymph nodes

Mechanism of Action

MBr1 binds to glycoconjugates (glycolipids, glycoproteins, mucins) on cancer cells . This interaction enables:

Immunohistochemical detection of tumor cells in formalin-fixed tissues .
Flow cytometry for identifying circulating tumor cells .
Complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) in therapeutic contexts .

Diagnostic Applications

In a study of 121 breast cancer patients, MBr1 detected micrometastases in 16.5% of bone marrow samples missed by conventional histology .
MBr1 positivity correlated with tumor aggressiveness and reduced survival in breast and small-cell lung cancer .

Therapeutic Potential

A chimeric mouse-human variant (γICHI-MBr1) retained tumor-binding specificity while enhancing ADCC and complement activation .
Clinical trials administering MBr1 (up to 16 mg) reported no severe toxicity, with transient side effects (fever, abdominal pain) at higher doses .

Comparative Analysis of MBr1 Formats

Format	Specificity	ADCC Activity	Clinical Use
Murine IgM (native)	High	Low	Diagnostics
Chimeric IgG1	High	High	Therapeutics

Recent Developments

Synthetic Vaccines: The tetrasaccharide epitope (Fucα1-2Galβ1-3GalNAcβ1-3Gal) is being explored as a component of anti-cancer vaccines .
Recombinant Antibodies: Engineered variants (e.g., humanized IgG1) show improved pharmacokinetics and reduced immunogenicity .

Product Specs

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Lead Time

Made-to-order (14-16 weeks)

Synonyms

mbr-1 antibody; T01C1.2 antibody; Mblk-1-related factor 1 antibody

Target Names

mbr-1

Uniprot No.

G5EGQ5

Target Background

Function

MBR-1 is a transcription activator that plays a crucial role in neurogenesis. It regulates neurite pruning between left and right AIM neurons and left and right RIF neurons during larval development, thereby contributing to the establishment of neuronal circuits. Additionally, MBR-1 regulates olfactory plasticity, influencing the adaptability of the olfactory system.

Gene References Into Functions

MBR-1, a helix-turn-helix transcription factor, is essential for the pruning of excessive neurites during larval stages. PMID: 16139210

Database Links

KEGG: cel:CELE_T01C1.2

STRING: 6239.T01C1.2

UniGene: Cel.443

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in AIM, RIC, AIZ, ADF, ADL, ASK, AWA, AUA, AIN, RIH (or RIR) and RIF head neurons and, in PVP, PVQ and DVA (or DVC) tail neurons, some intestinal cells, somatic gonad and vulva.

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mbr-1 Antibody