Function
MED15C Antibody is a component of the Mediator complex, a coactivator essential for the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator acts as a bridge, relaying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, which adopts a compact conformation in its free state, is recruited to promoters through direct interactions with regulatory proteins. This recruitment facilitates the assembly of a functional preinitiation complex involving RNA polymerase II and the general transcription factors.