METRN Antibody

Introduction to METRN Antibody

METRN Antibody targets the Meteorin protein encoded by the METRN gene (NCBI Gene ID: 79006). Meteorin regulates glial cell differentiation and promotes axonal extension in sensory neurons, making it vital for nervous system development . The antibody enables researchers to visualize METRN expression and study its mechanisms in vitro and in vivo.

Key Gene and Protein Details:

METRN shares paralogs like METRNL (Meteorin-like), which has distinct roles in immune regulation .

Research Applications of METRN Antibody

METRN Antibody (e.g., Aviva Systems Biology’s OACD05531) is validated for multiple applications :

Host Species: Rabbit
Clonality: Polyclonal
Reactivities: Mouse, Rat (predicted)
Immunogen: Recombinant METRN (Gly22–Asp291)

Key Research Findings

• Neurogenesis: METRN induces astrocyte differentiation and converts cerebellar astrocytes into radial glia, critical for neural circuit formation .

• Disease Links: METRN dysregulation is associated with Charcot-Marie-Tooth Disease Type 4, highlighting its potential as a therapeutic target .

• Mechanistic Insights: Studies using METRN Antibody have revealed its role in activating satellite glia to promote axonal growth in sensory neurons .

Clinical and Experimental Relevance

While METRN itself is distinct from the MET proto-oncogene (a receptor tyrosine kinase) , research tools like METRN Antibody help disentangle its unique functions. For example:

• Blocking METRN in vivo alters IL-4/13 signaling and macrophage polarization, suggesting immune-modulatory roles .

• METRN Antibody is critical for mapping its expression patterns in neurological disease models .