MIER1 Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchasing method or location. For specific delivery times, please contact your local distributor.
Synonyms
MIER1 antibody; KIAA1610 antibody; Mesoderm induction early response protein 1 antibody; Early response 1 antibody; Er1 antibody; Mi-er1 antibody; hMi-er1 antibody
Target Names
MIER1
Uniprot No.
Target Background
Function
MIER1 is a transcriptional repressor that regulates the expression of various genes, including those targeted by SP1. It is believed to function by recruiting HDAC1, a histone deacetylase involved in chromatin silencing.
Gene References Into Functions
- Biochemical analysis of the BAHD1-associated multiprotein complex revealed MIER proteins as novel partners of BAHD1, suggesting that the BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases. PMID: 26938916
- Insulin and IGF-1 alter the subcellular localization of MIER1alpha in breast carcinoma cells. PMID: 26281834
- Nuclear targeting of MIER1alpha requires an intact ELM2 domain and is dependent on interaction with HDAC1/2. PMID: 24376786
- This study presents the first immunohistochemical investigation of the MIER1alpha protein expression pattern in human tissues. PMID: 23277184
- Differential splicing alters the subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells. PMID: 22384264
- Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins, which may have significant implications for hMI-ER1 function. PMID: 12242014
- Our research explored the role of hMI-ER1alpha and hMI-ER1beta in transcription regulation. We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1). PMID: 12482978
- The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. PMID: 15117948
- Loss of nuclear MI-ER1 alpha might contribute to the development of invasive breast carcinoma. PMID: 18665173
Database Links
Subcellular Location
[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.; [Isoform 3]: Nucleus.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.
Tissue Specificity
Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
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