miga1 Antibody

Biological Functions of MIGA1

MIGA1 is a nucleus-encoded mitochondrial outer membrane protein critical for maintaining mitochondrial structure and function. Key roles include:

• Mitochondrial Fusion: MIGA1 forms homo- or heterodimers (with MIGA2) to stabilize mitochondrial outer membrane protein PLD6 (MitoPLD), facilitating mitochondrial fusion .

• Oocyte Maturation: MIGA1/2 double-knockout mice exhibit mitochondrial dysfunction (e.g., reduced ATP production, disrupted membrane potential) leading to impaired oocyte maturation and female subfertility .

• Granulosa Cell Proliferation: MIGA1/2 promote granulosa cell growth by regulating Hippo/YAP1 signaling. Overexpression enhances AKT phosphorylation and cell viability, while knockdown suppresses proliferation .

Key Research Findings

Recent studies highlight MIGA1's mechanistic roles:

Applications in Research

MIGA1 antibodies are pivotal for:

• Mitochondrial Studies: Validating MIGA1’s interaction with PLD6 and its role in fusion .

• Reproductive Biology: Assessing mitochondrial health in oocytes and granulosa cells during maturation .

• Cancer Research: Investigating YAP1/AKT-mediated cell proliferation pathways .