MMP12 Antibody

Gene References and Functions

1. A study conducted on a Bulgarian population investigated the association between the MMP12 -82 A>G promoter single nucleotide polymorphism (SNP) and bronchial asthma. The results suggest that the variant G allele of this polymorphism may be protective against the development of bronchial asthma. PMID: 29390099
2. Research indicates that MMP-12 could potentially serve as a target for the development of novel therapeutic agents for esophageal squamous cell carcinoma. PMID: 29033183
3. Studies have revealed an association between MMP-12 (-82A/G) polymorphisms and both the risk of obesity and its severity. PMID: 29317790
4. A meta-analysis has demonstrated a significant association between the MMP-12 (-1082 A/G) gene polymorphism and the risk of ischemic stroke (OR 2.55; 95% CI 1.75 to 3.71). PMID: 29906531
5. Downregulation of MMP12 through increased oxygen concentration has been observed to enable temporal expression control of MMP12. This process involves several mechanisms, including HIF-1alpha. These findings suggest a role for MMP12 in trophoblast invasion during the first trimester of pregnancy. PMID: 28990117
6. Research has demonstrated that hypoxia activates a HIF-KDM3A-MMP12 signaling cascade, promoting trophoblast invasion and the remodeling of uterine spiral arteries. PMID: 27807143
7. Current evidence suggests that the MMP12 rs652438 polymorphism, but not MMP12 rs2276109, may influence the risk of Parkinson's disease. PMID: 28655442
8. M4 macrophages have been identified as a potential source for HDAC9 and MMP12 expression in advanced human carotid plaques. PMID: 28343758
9. Elevated MMP12 levels have been observed in the gingival tissue of patients with periodontitis. MMP12-producing monocyte-derived cells exhibit reduced CD200R surface levels. The production of MMP12 by these cells is induced by CSF2, and treatment with a CD200R ligand has been shown to reduce CSF2-induced MMP12 production. This novel association between the CD200/CD200R pathway and MMP12 production by monocyte-derived cells may play a crucial role in the progression of periodontitis. PMID: 29101312
10. In the Bulgarian population, the G allele of the MMP12 -82 A > G promoter polymorphism has been identified as a protective factor for chronic obstructive pulmonary disease (COPD). PMID: 28692348
11. Studies have shown that MMP12 facilitates platelet aggregation, adhesion, and alpha granule secretion induced by type I collagen. Additionally, a short peptide, WYKG, has been found to facilitate type I collagen-induced platelet alpha granule secretion. These findings suggest that MMP12 expressed by platelets may contribute to platelet activation through the shedding of CEACAM1. PMID: 28385529
12. Research has indicated that Pseudomonas aeruginosa infection induces the expression of matrix metalloproteinases. The type III secretion system of Pseudomonas aeruginosa appears to be a key player in the expression of MMP-12 and MMP-13, which is further regulated by NF-kappaB signaling. PMID: 27377745
13. A study has demonstrated significantly higher levels of MMP-12 in patients with atheromatous plaques compared to those without plaques. PMID: 27345464
14. High MMP12 expression has been associated with gastric cancer. PMID: 28098914
15. A study evaluated MMP-12, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 levels in 40 patients with asymptomatic and symptomatic critical carotid artery stenosis (CAS) with neurologic symptoms onset within the preceding 12 hours. Results suggest that MMP-12 is related to critical CAS independently of symptoms. Furthermore, TIMP-3 and TIMP-4 seem to be specifically related to stroke. PMID: 27746079
16. Research has shown that MMP12 causes arterial stiffening in mice and suggests that it functions similarly in humans. PMID: 26608672
17. Paramagnetic NMR techniques have revealed a productive complex between MMP-12 and synthetic triple-helical collagen V. PMID: 26887942
18. Studies have confirmed increased MMP-12 expression in cutaneous melanoma, associated with tumor progression. These findings also provide the first evidence that MMP-12 levels could serve as an independent prognostic marker for patients with cutaneous melanoma. PMID: 26040769
19. Research has shown that fluid shear stress induces the synthesis of insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12. PMID: 25435370
20. The AG and GG genotypes of the MMP12 rs2276109 variant were found to be significantly under-represented among patients with non-contact anterior cruciate ligament rupture compared to controls. PMID: 21410539
21. HnRNP K can induce MMP12 expression and enzyme activity by activating the MMP12 promoter, promoting cell migration and invasion in nasopharyngeal carcinoma cells. PMID: 24885469
22. A novel association has been identified with an MMP12 locus in large artery atherosclerosis (rs660599; p = 2.5x10), with independent replication in a second population. PMID: 25078452
23. When human aortic endothelial stem cells (HAESCs) were co-cultured with microglia cells, thrombin-activated microglia expression of tumor necrosis factor-a, interleukin-1b, and MMP-12 was significantly reduced through contact-dependent and paracrine mechanisms. PMID: 24424266
24. Macrophage MMP12 has been found to regulate adipose tissue expansion, insulin sensitivity, and the expression of inducible nitric oxide synthase. PMID: 24914938
25. MMP12 is located in genes previously associated with chronic obstructive pulmonary disease susceptibility. PMID: 25006744
26. In patients with acute aortic dissection, macrophage activation is strongly related to the clinical outcome of atherosclerotic disease, with MMP-12 serving as a specific marker. PMID: 24432723
27. In emphysema, MMP12 mRNA expression has been inversely related to the diffusing capacity of the lung. PMID: 23900981
28. These findings suggest that inhibiting extracellular MMP-12 could offer a new avenue for the development of antiviral treatments. PMID: 24784232
29. The role of matrix metalloproteinase 12 in non-small cell lung cancer has been investigated. PMID: 24398311
30. MMP-12 proteolytic activity has been detected in aorta specimens and blood samples from patients with aortic dissection. PMID: 23642232
31. A study assessed the association between single nucleotide polymorphisms in MMP12 and MMP13 in patients with colorectal cancer (CRC) and healthy controls. PMID: 23898086
32. MMP-12 expression has been found to be significantly associated with extracapsular spread and correlated with nodal metastasis in head and neck squamous cell carcinoma. No relationship was found between MMP expression and survival. PMID: 22907031
33. A novel broad spectrum activity-based probe has been developed for detecting the endogenous matrix metalloprotease-12 active form. PMID: 23271741
34. The MMP12 rs2276109 gene polymorphism has been linked to susceptibility to asthma and is associated with asthma severity in a Japanese population. PMID: 23075521
35. Studies suggest that the inter-individual variability in the MMP-12 gene variation may not be a risk factor for vulnerable plaques in the Chinese Han population. PMID: 22863605
36. Researchers studied the catalytic domain of MMP-12 in complex with the known inhibitor CGS27023A. A 3D (15)N-edited/(14)N,(12)C-filtered ROESY experiment was employed to monitor and distinguish protein amide protons in fast exchange with bulk water. PMID: 22528292
37. Research has established microglia as a significant source of progranulin (PGRN) and identified MMP-12 as a modulator of PGRN. PMID: 22509390
38. The development of an orally potent and selective small molecule inhibitor of MMP-12 for the treatment of COPD and asthma in human and mouse models has been investigated. PMID: 22153340
39. Sputum MMP-12 concentrations and activity in patients with chronic obstructive pulmonary disease have been found to be associated with the extent of emphysema. PMID: 22305682
40. MMP-12 has been implicated in experimental small airway modeling and in emphysema. [review] PMID: 21920892
41. In vivo evidence of an effect of MMP12 on fibrinogen levels has been provided. PMID: 22119538
42. Surfaces of MMP-12 far from its active site have been found to affect degradation and affinity for elastin substrates. The main exosite 1 has been extended to Asp-124, which binds calcium, while exosite 2 comprises residues near the back of the catalytic domain. PMID: 21967233
43. The rs652438 SNP has been shown to alter MMP-12 activity, with the A allele exhibiting higher activity. This association is linked to increased macrophage infiltration and emphysema in the lungs of patients with COPD. These findings further implicate MMP-12 and this SNP in COPD. PMID: 21730350
44. MMP-12 mRNA has been identified as a valuable prognostic marker for both overall survival and tumor recurrence in hepatocellular carcinoma patients following liver resection. PMID: 21683576
45. High expression of MMP-12 in squamous laryngeal carcinoma has been linked to significant hyperplasia. PMID: 17357518
46. Data suggest that the matrix metalloproteinase-12 rs2276109 gene polymorphism may contribute to susceptibility to systemic sclerosis (SSc), particularly to diffuse cutaneous SSc and pulmonary fibrosis. PMID: 20595276
47. Overexpression of human macrophage metalloelastase has been strongly correlated with reduced angiogenesis and vascular invasion of gastric carcinoma. It may serve as a useful predictive indicator in patients with this disease. PMID: 20127415
48. The distribution of N357S genotypes was not found to be significantly different in chronic obstructive pulmonary disease. PMID: 20160424
49. Individuals with MMP-12 -82A/G and MMP-13 -77A/A may have a higher risk of developing overall or specific histological types of epithelial ovarian carcinoma. PMID: 20376807
50. The catalytic domain of MMP-12 binds to the triple helix and cleaves the typical sites -Gly(775)-Leu(776)- in alpha-2 type I collagen and -Gly(775)-Ile(776)- in alpha-1 type I and type III collagens. It also cleaves at multiple other sites in both collagen types. PMID: 19932771

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HGNC: 7158

OMIM: 601046

KEGG: hsa:4321

UniGene: Hs.1695