MMP28 Antibody, Biotin conjugated
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Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Shipping typically occurs within 1-3 business days of order receipt. Delivery times may vary depending on the shipping method and destination. Please contact your local distributor for precise delivery estimates.
Synonyms
Epilysin antibody; Matrix metalloproteinase 28 antibody; Matrix metalloproteinase-28 antibody; MM 28 antibody; MM28 antibody; MMP 25 antibody; MMP 28 antibody; MMP-28 antibody; MMP25 antibody; MMP28 antibody; MMP28_HUMAN antibody
Target Names
MMP28
Uniprot No.
Target Background
Function
MMP-28 is a matrix metalloproteinase capable of casein degradation. It is implicated in tissue homeostasis and repair.
Gene References Into Functions
MMP-28 Function and Associated Studies:
The following studies highlight the diverse roles of MMP-28 across various physiological and pathological contexts:
The following studies highlight the diverse roles of MMP-28 across various physiological and pathological contexts:
- Elevated circulating MMP-28 levels are observed in atrial fibrillation (PMID: 29729262).
- MMP-9 and TIMP1 mRNA levels increase, while MMP-28 decreases in large intestinal tissue, suggesting a role in colorectal carcinogenesis (PMID: 28293015).
- Significantly increased epilysin (MMP-28) expression is found in glioblastoma (PMID: 25429835).
- Coronary heart disease patients exhibit decreased IL-33 and elevated MMP-28 levels, correlating with disease severity (PMID: 24710352).
- Higher MMP28 mRNA expression is noted in healthy periodontal tissues compared to diseased tissues (PMID: 24167355).
- A seven-gene prognostic signature for triple-negative breast cancer (TNBC) includes MMP28 (PMID: 23549873).
- MMP28 overexpression protects against apoptosis induced by serum deprivation or protein kinase inhibitors (PMID: 22040290).
- MMP28 gene expression in intervertebral discs is donor-dependent and not consistently linked to degeneration or trauma (PMID: 21801383).
- Cigarette smoke influences the basal expression of MMP-28 in oral keratinocytes (PMID: 21723775).
- MMP28 overexpression contributes to gastric carcinoma progression, invasion, and metastasis (PMID: 21615884).
- Intervertebral disc expression and production of MMP28 have been documented (PMID: 20003223).
- MMP28 gene expression is regulated by Sp1 transcription factor acetylation (PMID: 20144149).
- MMP-21 and MMP-28 expression is associated with Merkel cell carcinoma of lesser malignant potential (PMID: 19921252).
- Epilysin (MMP-28) expression is linked to cell proliferation during epithelial repair (PMID: 12164918).
- Inhibition of MMP-28 may be beneficial in dysmyelination (PMID: 18778487).
- MMP28 expression alters keratinocyte phenotype, promoting adhesion and reducing migration (PMID: 19375502).
- Epilysin (MMP-28) is deposited in the basolateral extracellular matrix of epithelial cells (PMID: 19379669).
Database Links
Protein Families
Peptidase M10A family
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Tissue Specificity
Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is
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