Mono-methyl-H1F0 (K81) Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receipt. Delivery time may vary depending on your location and chosen shipping method. Please consult your local distributor for specific delivery timelines.
Synonyms
H1 histone family member 0 antibody; H1(0) antibody; H10 antibody; H10_HUMAN antibody; h1f0 antibody; H1FV antibody; Histone H1'' antibody; Histone H1(0) antibody; Histone H1.0 antibody; Histone H10 antibody; Histone H5 antibody; MGC5241 antibody; N-terminally processed antibody
Target Names
H1F0
Uniprot No.
Target Background
Function
Histones H1 play a crucial role in the condensation of nucleosome chains into higher-order structures. Histone H1.0 is specifically found in cells that have reached terminal differentiation or exhibit low rates of cell division.
Gene References Into Functions
- H1.X exhibits faster mobility compared to other linker histones in vivo. Domain swapping experiments between H1.0 and H1.X indicate that both the globular domain (GD) and C-terminal domain (CTD) of H1.X contribute independently to the dynamic behavior of H1.X. PMID: 27528617
- Research suggests that dynamic epigenetic states regulated by the linker histone H1.0 determine which cells within a tumor can sustain long-term cancer growth. PMID: 27708074
- The N-terminal domain contributes to the differential chromatin binding affinity, whereas the C-terminal domain influences the distinct nucleosomal interface of isotypes H10 and H1c. PMID: 22334665
- Nuclear transport of H1 histones relies on a heterodimeric nuclear import receptor. PMID: 12080050
- H1(0) histone might be a significant factor in normal dendritic cell differentiation. Tumor-derived factors could potentially inhibit dendritic cell differentiation by influencing H1(0) expression. PMID: 12149419
Database Links
Protein Families
Histone H1/H5 family
Subcellular Location
Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
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