MOV10 Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days after receiving them. Delivery time may vary depending on the purchasing method or location. For specific delivery times, please consult your local distributors.
Synonyms
MOV10 antibody; KIAA1631 antibody; Helicase MOV-10 antibody; EC 3.6.4.13 antibody; Armitage homolog antibody; Moloney leukemia virus 10 protein antibody
Target Names
Uniprot No.
Target Background
Function
MOV10 is a 5' to 3' RNA helicase that plays a crucial role in the degradation of UPF1 mRNA targets by translocating along 3' UTRs. It is essential for microRNA (miRNA)-mediated gene silencing through the RNA-induced silencing complex (RISC). MOV10 is involved in both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In collaboration with FMR1, it regulates miRNA-mediated translational repression by AGO2. MOV10, in conjunction with TUT4 and TUT7, restricts the retrotransposition of long interspersed element-1 (LINE-1) by counteracting the RNA chaperonne activity of L1RE1. It facilitates LINE-1 uridylation by TUT4 and TUT7. MOV10 is critical for embryonic viability and normal development and function of the central nervous system. It plays two essential roles in early brain development: suppressing retroelements in the nucleus by directly inhibiting cDNA synthesis and regulating cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. MOV10 might function as a messenger ribonucleoprotein (mRNP) clearance factor. It exhibits antiviral activity against dengue virus (DENV). Additionally, MOV10 is required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). It interacts with small capped HDV RNAs derived from genomic hairpin structures, marking the initiation sites of RNA-dependent HDV RNA transcription.
Gene References Into Functions
- MOV10 enhances the level of apolipoprotein-B-mRNA-editing enzyme catalytic polypeptide-like 3G in HIV-1-infected cells and virions by interfering with the ubiquitin-proteasome system. This synergistic effect inhibits HIV-1 replication and infectivity. PMID: 29258557
- These findings identify MOV10, a conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses. It utilizes an retinoic acid-inducible gene I-like receptor-independent pathway to enhance IFN response. PMID: 27016603
- IRAV, an RNA binding protein, localizes to cytoplasmic processing bodies (P bodies) in uninfected cells. It interacts with the MOV10 RISC complex RNA helicase, suggesting a role in viral RNA processing. PMID: 27974568
- MOV10, a highly conserved cellular protein belonging to the SF1 helicase family, plays crucial roles in EV71 infection. PMID: 27666477
- MOV10 acts as an anti-influenza virus factor by specifically inhibiting the nuclear transportation of nucleoprotein and subsequently inhibiting the function of the viral ribonucleoprotein complex. PMID: 26842467
- The DEAG-box of human MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export. PMID: 26379090
- Endogenous Mov10 can promote hepatitis B virus replication in vitro. PMID: 25533532
- MOV10 exhibits a dual function in regulating translation: it facilitates microRNA-mediated translation of certain RNAs, but also increases the expression of other RNAs by preventing AGO2 function. PMID: 25464849
- Results show that MOV10 primarily binds to 3' UTRs upstream of regions predicted to form local secondary structures. Evidence suggests that MOV10 helicase mutants are impaired in their ability to translocate 5' to 3' on their mRNA targets. PMID: 24726324
- Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population. PMID: 24338417
- MOV10 contributes to the cellular control of long interspersed element 1 replication. PMID: 23754279
- Authors conclude that HIV-1 virion incorporation and the antiviral activities of Mov10 and APOBEC3G do not require their localization to P bodies. PMID: 23926332
- Depletion of endogenous MOV10 significantly enhances the retrotransposition of endogenous retroelements. PMID: 22727223
- APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. PMID: 22791714
- Two critical MOV10 packaging determinants and eight other critical residues for anti-HIV-1 activity were identified. PMID: 22105071
- Results suggest that Mov10 could be required during the lentiviral lifecycle and its perturbation disrupts the generation of infectious viral particles. PMID: 20140200
- MOV10 co-purifies and interacts with components of Polycomb-repressive complex 1 from human cells. Knockdown of MOV10 in human fibroblasts leads to the upregulation of the INK4a. PMID: 20543829
- The identification of capped small RNAs and the involvement of MOV10 in hepatitis delta virus replication further suggest a conserved mechanism related to RNA-directed transcription in lower eukaryotes. PMID: 18552826
- These data suggest that MOV10 is involved in the progression of telomerase-catalyzing reaction through the interaction of telomerase protein and telomere DNA. PMID: 19665004
- Mov10 coimmunoprecipitates with human Ago1 and Ago2 and also colocalizes with them in cytoplasmic P-bodies. PMID: 16289642
Database Links
Protein Families
DNA2/NAM7 helicase family, SDE3 subfamily
Subcellular Location
Cytoplasm, P-body. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Nucleus. Cytoplasm.
Customer Reviews
,
B.A
By Anonymous
★★★★★
Applications : WB
Review: Western blotting analysis with specific antibodies of the eluates of a representative RIC experiment in SINV-infected HEK293 cells.
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