msrb1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
msrb1 antibody; sepx1 antibody; sepx1a antibody; Methionine-R-sulfoxide reductase B1-A antibody; MsrB antibody; MsrB1-A antibody; EC 1.8.4.12 antibody; EC 1.8.4.14 antibody; Selenoprotein X-A antibody; SePR antibody; SelX-A antibody
Target Names
msrb1
Uniprot No.
Target Background
Function
MSRB1 is a methionine-sulfoxide reductase that specifically catalyzes the reduction of methionine (R)-sulfoxide back to methionine. While methionine oxidation often arises from random oxidation during oxidative stress, it can also serve as a post-translational modification on specific residues. MSRB1 acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide residues on actin, which are modified by MICALs (MICAL1, MICAL2, or MICAL3). This reduction promotes filament repolymerization. MSRB1 plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Database Links
Protein Families
MsrB Met sulfoxide reductase family
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
Tissue Specificity
In the embryo, expressed in the polster, paraxial mesoderm, tectum, otic vesicle and liver.
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