MSR1 Antibody

Introduction to MSR1 Antibody

The MSR1 Antibody is a critical tool for detecting and studying Macrophage Scavenger Receptor 1 (MSR1/CD204), a transmembrane glycoprotein involved in lipid metabolism, pathogen clearance, and immune regulation . MSR1 is primarily expressed on macrophages and dendritic cells, where it binds oxidized low-density lipoproteins (LDL), bacterial components, and viral particles, playing dual roles in host defense and disease progression . Antibodies targeting MSR1 enable researchers to investigate its expression, localization, and functional mechanisms in conditions such as atherosclerosis, cancer, and autoimmune disorders .

Autoimmune Disease Mechanisms

• In K/BxN mouse models, Msr1 deficiency reduced autoantibody production and arthritis severity. MSR1 antibodies confirmed its role in autoantigen (GPI) clearance, influencing B cell activation .

• Flow cytometry using MSR1 antibodies revealed elevated receptor expression on B cells and monocytes in asthma and COPD patients .

Viral Infection Studies

• MSR1 antibodies demonstrated its antiviral role in Chikungunya virus (CHIKV) infection. Msr1−/− mice showed reduced autophagy and increased viral replication, highlighting MSR1’s interaction with ATG12-ATG5-ATG16L1 complexes .

Cancer Research

• MSR1 antibodies identified tumor-associated macrophages (TAMs) in ovarian and pancreatic cancers. Targeting MSR1 with fucoidan or photodynamic therapy conjugates inhibited tumor growth by >80% in preclinical models .

Therapeutic Implications

MSR1 antibodies are pivotal in developing targeted therapies:

• Cancer: Sodium alginate-phthalocyanine conjugates exploit MSR1’s ligand-binding ability for TAM-specific photodynamic therapy, achieving 87% tumor growth inhibition .

• Sepsis: Berberine alkaloids block MSR1-mediated LPS uptake, reducing caspase-11 activation and endotoxin-induced coagulation .

• Atherosclerosis: Antibodies validate MSR1’s role in oxidized LDL uptake, informing drug candidates to modulate lipid deposition .

Future Directions

Current research focuses on:

• Biomarker Development: MSR1 antibodies are evaluating its prognostic value in lung cancer and chronic inflammatory diseases .

• Gene Editing: CRISPR/Cas9-mediated MSR1 knockout models are clarifying its dual pro-/anti-inflammatory roles in sepsis .

• Nanoparticle Targeting: Antibody-conjugated nanoparticles are being tested for MSR1-specific drug delivery in atherosclerosis .