MTPC1 Antibody

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Description

Analysis of Potential Nomenclature Errors

The term "MTPC1" may represent a typographical error or misinterpretation of established abbreviations. Below are related antibodies with nomenclature similarities:

Similar TermDescriptionRelevant AntibodiesSource
MTP Antibody (C-1)Targets microsomal triglyceride transfer protein (MTTP), critical for lipid metabolismMouse monoclonal IgG1 (Catalog: sc-515742); detects MTTP in WB, IP, IHC, and ELISA applications. Conjugated variants available (HRP, FITC, Alexa Fluor).
MTFP1 AntibodyRecognizes mitochondrial fission process protein 1 (MTFP1), regulates apoptosisRabbit polyclonal antibodies (e.g., PA5-50457, ab198217); validated for WB and IHC in human/mouse samples.

MTP/MTTP Antibodies

Key Product: MTP Antibody (C-1)

  • Applications: Western blot, immunohistochemistry, immunofluorescence

  • Species Reactivity: Human, mouse, rat

  • Conjugates: HRP, FITC, PE, Alexa Fluor® variants (e.g., AF488, AF647)

  • Role in Disease: Linked to abetalipoproteinemia due to MTTP dysfunction .

MTFP1/MTP18 Antibodies

AntibodyHostApplicationsKey Findings
PA5-50457RabbitWB, IHCRegulates mitochondrial fission; knockdown induces cytochrome c release .
ab198217RabbitWB, IHC-PValidated in HeLa, HepG2 lysates; predicts 18 kDa band size in mouse tissues .

Research Implications of Unverified Targets

While "MTPC1" lacks scientific recognition, novel antibody development typically follows these steps:

  1. Target Identification: CRISPR screens or proteomic studies to define disease-associated biomarkers.

  2. Epitope Mapping: Phage display/hybridoma technology for antibody generation.

  3. Validation: Binding affinity (e.g., SPR, ELISA) and functional assays (e.g., ADCC, apoptosis).

Recommendations for Further Investigation

  • Confirm target nomenclature via genomic databases (e.g., NCBI Gene, UniProt).

  • Explore antibodies against analogous targets (e.g., MTFP1, MTTP) with established roles in metabolic or oncologic pathways.

  • Consult antibody repositories (CiteAb, Antibody Registry) for updated listings.

Product Specs

Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks lead time (made-to-order)
Synonyms
MTPC1; MTP6; At2g47830; F17A22.22; Metal tolerance protein C1; AtMTPc1; AtMTP6
Target Names
MTPC1
Uniprot No.

Target Background

Function
This antibody targets MTPC1, a protein involved in the sequestration of excess cytoplasmic metals into vacuoles, thereby maintaining cellular metal homeostasis.
Database Links

KEGG: ath:AT2G47830

STRING: 3702.AT2G47830.1

UniGene: At.43449

Protein Families
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Subcellular Location
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.

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