mug115 Antibody

CD115 (CSF-1R) Overview

CD115, encoded by the Csf1r gene, is a receptor tyrosine kinase critical for monocyte/macrophage differentiation, osteoclastogenesis, and tumor-associated macrophage (TAM) regulation . It binds CSF-1 and IL-34, activating pathways for cell survival, proliferation, and immune modulation .

Key Anti-CD115 Antibodies

Mechanisms and Therapeutic Applications

• Cancer Immunotherapy:

  • AFS98 delays tumor growth in murine models (e.g., EL4 lymphoma, PyMT mammary tumors) by depleting pro-tumorigenic M2 macrophages .

  • Reduces osteoclast differentiation and bone metastasis in breast cancer models .

• Autoimmune/Inflammatory Disorders:

  • CD115 inhibition modulates macrophage-driven inflammation, though clinical data in humans remain limited .

Research Gaps and Limitations

• No studies explicitly address an antibody named "mug115."

• Most data derive from preclinical mouse models; human clinical trials for anti-CD115 antibodies are sparse .