CBP20 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
CBP20 antibody; At5g44200 antibody; MLN1.12 antibody; Nuclear cap-binding protein subunit 2 antibody; 20 kDa nuclear cap-binding protein antibody; NCBP 20 kDa subunit antibody; AtCBP20 antibody
Target Names
CBP20
Uniprot No.
Target Background
Function
CBP20 is a component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs. This complex plays a crucial role in various cellular processes, including pre-mRNA splicing and RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs). The CBC complex is actively involved in miRNA-mediated RNA interference and is essential for primary miRNA processing. Within the CBC complex, CBP20 specifically recognizes and binds capped RNAs (m7GpppG-capped RNA). However, it requires ABH1/CBP80 for stabilization of its N-terminal loop, ensuring that the CBC is locked into a high-affinity cap-binding state with the cap structure. Notably, CBP20 also contributes to the stabilization of ABH1/CBP80 and facilitates its localization to the nucleus. Furthermore, CBP20 participates in flowering regulation through its interaction with FRIGIDA.
Gene References Into Functions
- Studies have revealed hitherto undescribed changes in the tissue structure and epidermal morphology of cbp20 mutant plants. PMID: 21143728
- The N-terminal region of AtCBP20 is critical for the formation of a complex with AtCBP80. PMID: 19453442
Database Links
Protein Families
RRM NCBP2 family
Subcellular Location
Nucleus. Cytoplasm. Note=Predominantly nuclear.
Tissue Specificity
Expressed in all tissues analyzed, including roots, stems, leaves and flowers.
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