NFATC4 Antibody
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Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. Delivery time may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery details.
Synonyms
cytoplasmic 4 antibody; NF ATc4 antibody; NF-AT3 antibody; NF-ATc4 antibody; NFAC4_HUMAN antibody; NFAT3 antibody; NFATc4 antibody; Nuclear factor of activated T cells cytoplasmic 4 antibody; Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4 antibody; Nuclear factor of activated T-cells antibody; T cell transcription factor NFAT3 antibody; T-cell transcription factor NFAT3 antibody
Target Names
Uniprot No.
Target Background
Function
NFAT3, a calcium-regulated transcription factor, plays a critical role in various biological processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. It is implicated in T-cell activation by stimulating the transcription of cytokine genes, such as IL2 and IL4. Along with NFATC3, NFAT3 is involved in embryonic heart development. It contributes to mitochondrial energy metabolism essential for cardiac morphogenesis and function. NFAT3 transactivates numerous genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF, and MYH7/beta-MHC. NFAT3 participates in regulating adult hippocampal neurogenesis and BDNF-driven pro-survival signaling in hippocampal adult-born neurons. It is involved in the formation of long-term spatial memory and long-term potentiation. In cochlear nucleus neurons, NFAT3 may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons rely on afferent input for survival. It binds to and activates the BACE1/Beta-secretase 1 promoter, potentially regulating the proteolytic processing of the amyloid precursor protein (APP). NFAT3 plays a role in adipocyte differentiation and may be involved in myoblast differentiation into myotubes. It binds to the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, NFAT3 activates TNF transcription. It binds to the PPARG gene promoter and regulates its activity. Additionally, it binds to PPARG and REG3G gene promoters.
Gene References Into Functions
- TBX5 deficiency-mediated downregulation of NFAT3 is crucial for the high cytokine-producing activity of T cells PMID: 29180489
- These findings provide evidence supporting the oncogenic potential of NFAT3 and suggest that CDK3-mediated phosphorylation of NFAT3 plays a significant role in skin tumorigenesis. PMID: 27893713
- The Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is essential for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. PMID: 27307045
- NFAT3 expression plays a role in regulating CXCR4 expression. PMID: 25514788
- This is the first study to provide evidence of new and distinct roles for NFAT3 and SMAD3 in the osteoarthritis process in the regulation of miR-140 transcription PMID: 24257415
- Expression levels of PPP3R1 and GATA4, and NFATC4 genes for transcription factors did not differ in the studied subgroups of patients. PMID: 23888774
- Syndecan-4 is essential for the development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway PMID: 22164265
- Dendritic spine loss and dendritic branching simplification induced by amyloid-beta peptide exposure are mimicked by constitutively active NFATC4 and abolished when NFATC4 activation is blocked by the genetically encoded inhibitor VIVIT. PMID: 22378890
- Polymorphisms in the NFATc4 gene may confer certain protection or predisposition for new-onset diabetes after transplantation (NODAT). PMID: 22234350
- These data suggest that the opposing transcriptional activities of FoxP1 and Nfat3 maintain cardiomyocyte homeostasis. PMID: 21606195
- The expression of COX-2 was significantly associated with the expressions of transcription factors NFAT3 and c-Fos in nonsmall cell lung cancer. PMID: 21081043
- A previously unknown NFAT3/LCN2 axis critically controls motility in breast cancer PMID: 20101218
- Data demonstrate that inhibition of NFAT3 activation by shNFAT3 significantly downregulated tumor necrosis factor (TNF)-alpha induction, its receptor TNFR1, caspase 10, caspase 3, and poly (ADP-ribose) polymerase. PMID: 19784808
- Polymorphism of the NFATC4 gene plays a role in the development of human cardiac hypertrophy. PMID: 12939651
- NFAT3 may play a role in estrogen receptor signaling in breast cancer cells PMID: 16219765
- This study demonstrates that silica was able to activate NFAT3 in an oxygen radical-dependent manner, which was required for TNF-alpha induction. PMID: 16489119
- Ionizing radiation is able to enhance cyclin D1 transcription induced by B[a]PDE, and NFAT3 is involved in the regulation of cyclin D1 transcription by B[a]PDE or B[a]PDE plus ionizing radiation PMID: 16645724
- Neuronal nuclear translocation of NFAT requires a functional cytoskeleton. PMID: 17044076
- Overexpression of NFAT3 in cell lines originating from the kidney decreased dose-dependently both ERalpha and ERbeta transcriptional activities in a ligand-independent manner. PMID: 17194453
- RSK2 is an important kinase for NFAT3 in mediating myotube differentiation PMID: 17213202
- Results provided direct evidence for the anti-oncogenic potential of the NFAT3 transcription factor. PMID: 17875713
- Data show that the calcineurin pathway is activated in hypertrophic myocardium as demonstrated by increased calcineurin activity and expression of calcineurin A-beta and B, and GATA-4, and a shift of cytoplasmic NFAT-3 into the nucleus. PMID: 18034994
- The estrogen receptor may play a critical role in the regulation of NFAT3 transcriptional activity PMID: 18668201
Database Links
Subcellular Location
Cytoplasm, cytosol. Nucleus.
Tissue Specificity
Widely expressed, with high levels in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. In the hippocampus, expressed in the granular layer of the dentate gyrus, in the pyramidal neurons of CA3 region, and in the hippocampal
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