NKp46 Human
Description
NKp46 triggers cytotoxicity and cytokine production through ligand engagement:
Key Functions
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Cytotoxicity:
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Immune Synapse Formation:
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Cytokine Regulation:
Ligand Interactions
Role in Disease
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Cancer:
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Autoimmunity:
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Infections:
Therapeutic Applications
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Antibody-Based Therapies:
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Biomarker Potential:
Research Advancements
Recent studies highlight novel mechanisms and applications:
Key Findings
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ILC1 Regulation:
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Immune Synapse Dynamics:
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Species-Specific Models:
Challenges and Future Directions
Product Specs
Recombinant human NKp46, produced in E. coli, is a single, non-glycosylated polypeptide chain encompassing 235 amino acids (22-255). With a molecular weight of 26.6 kDa, this protein is purified using proprietary chromatographic techniques.
The NKp46 solution is provided at a concentration of 1 mg/ml in phosphate-buffered saline (pH 7.4) containing 1 mM EDTA.
The purity of this product exceeds 95.0% as determined by SDS-PAGE analysis.
MQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINKVKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEEV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRX FGSYNNHAWSFPSEPVKLLV TGDIENTSLA PEDPTFSADT WGTYLLTTET GLQKDHALWD HTAQN.
Product Science Overview
Natural Cytotoxicity Receptor NKp46, also known as NCR1, is a crucial activating receptor found on the surface of Natural Killer (NK) cells. NK cells are a type of lymphocyte that play a significant role in the innate immune system by targeting and destroying tumor cells and virus-infected cells. NKp46 is one of the three main Natural Cytotoxicity Receptors (NCRs), alongside NKp30 and NKp44, which are involved in the non-MHC-restricted recognition of target cells .
NKp46 is a type I transmembrane protein that belongs to the immunoglobulin superfamily. It contains two extracellular immunoglobulin-like domains, a transmembrane domain, and a short cytoplasmic tail. The receptor is capable of recognizing and binding to various ligands expressed on the surface of tumor cells and virus-infected cells .
The activation of NKp46 triggers a cascade of intracellular signaling events that lead to the release of cytotoxic granules and the production of cytokines, ultimately resulting in the lysis of the target cells . NKp46 is also involved in the regulation of NK cell development and function, contributing to the overall immune response.
NKp46 recognizes a diverse set of ligands, including both host- and pathogen-encoded molecules. These ligands can be expressed on the surface of target cells or secreted extracellularly, highlighting the receptor’s polyfunctionality . The ability of NKp46 to bind to multiple ligands allows NK cells to effectively target a wide range of abnormal cells, including those that have downregulated MHC class I molecules to evade immune detection.
NKp46 plays a critical role in the immune surveillance of tumors and viral infections. In healthy individuals, NKp46 helps maintain immune homeostasis by targeting and eliminating abnormal cells. However, dysregulation of NKp46 expression or function can contribute to the development of various diseases, including cancer and autoimmune disorders .
The unique properties of NKp46 make it an attractive target for therapeutic interventions. Researchers are exploring ways to harness NKp46 for cancer immunotherapy, aiming to enhance the cytotoxic activity of NK cells against tumor cells. Additionally, understanding the synergy between NKp46 and other co-activating signals could pave the way for more effective NK cell-based therapies .
