NMAT3 Antibody

Definition and Biological Context

NMAT3 (AT5G04050) is a nuclear-encoded mitochondrial maturase protein in Arabidopsis thaliana, critical for splicing mitochondrial introns and complex I biogenesis during early embryogenesis . The term "NMAT3 Antibody" may refer to antibodies targeting this protein, though no commercial therapeutic antibodies against NMAT3 are currently approved or listed in global databases .

Research Findings on NMAT3 Function

• Role in Mitochondrial Splicing: NMAT3 facilitates the splicing of nad1 introns (i1, i3, i4) in plant mitochondria, essential for complex I assembly . Knockout mutants exhibit embryo-lethality and respiratory defects .

• Localization and Expression: Localizes to mitochondria, with peak expression during germination and early development .

Antibodies Targeting NMDA Receptors (Unrelated to NMAT3)

A potential source of confusion arises with anti-NMDA receptor antibodies, which target GluN1 subunits in humans. These antibodies are implicated in autoimmune encephalitis and schizophrenia . Key findings include:

• Epitope Mapping: Cryo-EM studies reveal binding to the N-terminal domain (NTD) of GluN1 subunits, specifically the R1 lobe .

• Therapeutic Relevance: While no NMAT3-specific antibodies are approved, anti-NMDA receptor antibodies remain a focus in neuroimmunology .

Approved Antibody Therapeutics (2024 Data)

A global database of antibody therapeutics (Table 1) lists 1,200+ products, but none target NMAT3 .