NMB Human
Description
Biological Functions and Mechanisms
NMB Human exerts its effects via the G-protein coupled neuromedin B receptor (NMBR), influencing pathways such as:
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Smooth Muscle Contraction: Mimics bombesin’s action on gastrointestinal and respiratory systems .
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Metabolic Regulation:
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Immune Modulation: Enhances IFN-α expression and reduces IL-6 during influenza A infection .
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Cancer Progression:
Cancer Biomarker Potential
NMB demonstrates diagnostic and prognostic value in GBM:
| Parameter | Value | Source |
|---|---|---|
| AUC (ROC Analysis) | 0.984 (95% CI: 0.971–0.997) | |
| Sensitivity | 96.4% | |
| Specificity | 96.2% | |
| Survival Benefit | High vs. low expression: 16.3 vs. 12.7 months |
Immunohistochemical staining confirms elevated NMB protein in GBM tissues compared to normal brain .
Recombinant Applications
NMB Human Recombinant (PRO-1518) is used in laboratory research for:
Expression and Regulation
Product Specs
Product Science Overview
The genes encoding Neuromedin B and its receptor (NMBR) have been cloned and analyzed in various species. Studies have shown that the amino acid sequences and gene structures of NMB and NMBR are highly conserved across different species . This conservation suggests that Neuromedin B has essential physiological roles that have been maintained throughout evolution.
Neuromedin B performs a variety of physiological functions through its interaction with the NMBR. These functions include:
- Smooth Muscle Contraction: NMB stimulates smooth muscle contraction in a manner similar to bombesin .
- Reproductive Functions: NMB and NMBR are expressed in the reproductive axis, with varying expression levels during different phases of the estrous cycle in females and postnatal development stages in males .
- Central Nervous System: NMB is primarily expressed in the CNS, where it may play a role in regulating various neurological functions .
Recombinant human Neuromedin B is produced using recombinant DNA technology. This involves inserting the gene encoding NMB into a suitable expression system, such as E. coli, to produce the peptide in large quantities. The recombinant protein is often tagged with a His-tag to facilitate purification and detection .
The recombinant human Neuromedin B protein is used in various research applications to study its physiological functions and potential therapeutic uses. It is essential for understanding the role of NMB in health and disease and for developing potential treatments targeting the NMB/NMBR system.
