NOS1 (Ab-852) Antibody

1. Variations in the NOS1 gene have been linked to Raynaud's phenomenon. PMID: 29698501
2. A meta-analysis investigated the association of ten single nucleotide polymorphisms (SNPs) in the NOS1 gene with schizophrenia. The rs3782206 SNP showed a strong association with schizophrenia in various genetic models among Asian populations. In Caucasian populations, rs499776 was associated with schizophrenia in several genetic models. PMID: 28795310
3. A quantitative comparison of dendritic characteristics in human and rat NOS1 neurons revealed a statistically significant difference between the two species. PMID: 28720408
4. Studies have observed a higher ratio of G/T and T/T genotypes in the neuronal NOS exon 7 in individuals with osteonecrosis of the femoral head compared to controls. Additionally, the neuronal NOS intron 4 exhibited a significantly higher a/b genotype in the experimental group. These findings suggest that neuronal NOS gene mutations may contribute to the development of osteonecrosis of the femoral head. PMID: 28770971
5. High NOS1 expression has been associated with dilated cardiomyopathy. PMID: 27481317
6. Variations in the NOS1 exon 1f VNTR have been linked to white matter microstructure in females with ADHD and healthy females. PMID: 28589541
7. Studies in a North Indian population suggest that selected nNOS polymorphisms do not significantly contribute to Parkinson's disease risk. PMID: 26081147
8. Lysophosphatidylcholine has been shown to induce nNOS uncoupling and phosphorylation of nNOS at Ser852, reducing NO and H2O2 production and enhancing superoxide production by modulating ERK1/2 activity in endothelial cells. PMID: 28235709
9. A missense variant in NOS1 (rs79487279) has been associated with bipolar disorder. PMID: 28195573
10. Research suggests that NOS1 and NOS2 play roles in the stress-induced surge in nitric oxide (NO) production, and NO serves as a mediator in the development of secondary neurological disorders associated with stress, such as anxiety and anxiety disorders. PMID: 28061969
11. nNOS mediates the human coronary vasodilator response to mental stress, primarily through actions at the level of coronary resistance vessels. PMID: 28646032
12. These findings highlight a key role of the TLR4-NOS1-AP1 signaling axis in regulating macrophage polarization. PMID: 28013342
13. An association between NOS1 and PTSD severity and stress has been found. NOS1 has also been linked to resilience. PMID: 28465168
14. Data indicate that metastasis associated 1 (MTA1) represses neuronal nitric oxide synthase (nNOS) expression upon oxygen glucose deprivation (OGD)-induced oxidative stress. PMID: 27603575
15. Superoxide generation from NOS1 splice variants and its potential involvement in redox signal regulation has been described. PMID: 28126743
16. The expression of neuronal NOS heterodimers in insect cells, utilizing an exogenous heme-triggered chaperone-assisted assembly process, has resulted in an approximately 43% yield in heterodimeric NOS. PMID: 27487179
17. NOS1 ex1f-VNTR has been associated with anxiety-related traits. PMID: 26746182
18. The NOS1 exon 18 variants might play a role in the risk of Parkinson's disease (Meta-Analysis). PMID: 27749554
19. nNOS gene variants have been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). PMID: 27739347
20. Findings demonstrate that the upregulation of cardiac NOS1 is not accompanied by an increase in NOS activity; it is partially translocated to the sarcolemma in ischemic hearts with a direct relationship between its protein levels and systolic ventricular function. These results indicate that NOS1 may be significant in the pathophysiology of human ischemic heart disease. PMID: 27041589
21. The results of this study suggested possible roles of the NOS1 gene in working memory performance in ADHD patients. PMID: 26233433
22. NOS1 rs7977109 and rs693534 genotypes and allelic variants have not been associated with the risk for migraine in Caucasian Spanish people. PMID: 26283425
23. These findings from this study suggest that SNAP25 and NOS1 genotypes influence ADHD symptoms only in adults with ADHD. PMID: 26821215
24. CoCl2 has been shown to increase nNOS expression and NO production in human neuroblastoma SK-N-SH cells by increasing HIF-1a expression and binding to a hypoxia response element in the nNos promoter. PMID: 26458913
25. Polymorphisms in the NOS1 gene may be useful in identifying women at risk for osteoporosis. PMID: 25871004
26. DLC1 binding to the nNOS-calmodulin complex does not affect the electron transport from the reductase to the oxygenase domain. PMID: 26923072
27. This study concludes that DNM2 is a novel negative regulator of NO production in mouse collecting ducts. PMID: 26791826
28. Analysis of the interaction between nNOS and dystrophin repeats 16 and 17 has been conducted. PMID: 26378238
29. The first structure of human neuronal nitric oxide synthase has been determined. PMID: 25286850
30. This study demonstrated, for the first time, the highest Red Blood Cell (RBC)-Nitric Oxide Synthase activation and nitric oxide production in old RBCs. PMID: 25902315
31. Results suggested a link between the NOS1 gene polymorphism at rs3782206 and cognitive functions and their neural underpinnings at the right inferior frontal gyrus. PMID: 25490993
32. The tetrahydrobiopterin:dihydrobiopterin ratio is lower in tumor tissues, and consequently, NOS activity generates more peroxynitrite and superoxide anion than nitric oxide, resulting in significant tumor growth-promoting and antiapoptotic signaling properties. PMID: 25724429
33. This study found no significant differences in the frequencies of the NOS1 rs7977109 and rs693534 genotypes or in the frequencies of the allelic variants of these SNPs in restless legs syndrome patients when compared with healthy controls. PMID: 25300364
34. This study investigated and determined the localization of neuronal NOS (nNOS) in human airway epithelium. PMID: 25460324
35. The T allele of rs2293050 and A allele of rs2139733 in the nNOS gene may contribute to increased susceptibility of LAA-caused ischemic stroke in Han Chinese. PMID: 24668187
36. Results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter an individual's susceptibility to depression. PMID: 24917196
37. This review discusses the idea that post-translational modifications of Ca2+ regulatory proteins via aberrant neuronal nitric oxide synthase (NOS1)-mediated nitroso-redox balance contribute to contractility defects in heart failure. PMID: 24801117
38. 2-methoxyestradiol specifically affects neuronal nitric oxide synthase and augments 3-nitrotyrosine levels, leading to osteosarcoma and immortalized hippocampal cell death. PMID: 25170949
39. Increased cellular expression of nNOS was accompanied by elevated NO generation in the brains of heroin addicts and may have contributed to some of the known toxic effects of heroin. PMID: 23953641
40. Results identified NOS1 as a novel nitric oxide target in human skeletal muscle controlled by activity-driven auto-nitrosylation mechanisms. PMID: 24251120
41. rADI not only reduced NO production but also caused cellular toxicity in nNOS-activated SH-SY5Y cells, suggesting a dual role for rADI in NOS-mediated neurotoxicity. PMID: 25126568
42. DNA methylation of NOS1 plays a role in atherogenesis through regulation of NO production. PMID: 24622112
43. This review will focus on the role of Nitric Oxide Synthases (NOSes) and the role they play in the pathogenesis of subarachnoid hemorrhage. PMID: 25366612
44. The NOS1 rs41279104 CT genotype was associated with good responders in postoperative ED patients. PMID: 24897285
45. This study investigated which NOS gene variants are most strongly associated with coronary heart disease (CHD) and hypertension and confirmed NOS1 as the most important NOS risk gene for CHD. PMID: 24713495
46. Population genetic variability in Sardinia (Italy) shows a positive and highly significant correlation between mortality determined by malaria infection and alleles (TGGA)7 of NOS2, (AAAAG)2 and (ATTT)10 of adNOS1, and (AAACA)11 of adNOS3 genes. PMID: 24573959
47. The results of this study demonstrated that the risk allele significantly decreases expression of NOS1 in the prefrontal cortex in patients with schizophrenia. PMID: 24220657
48. Genetic or pharmacologic inhibition of NOS1 reduced the growth of CXCL14-expressing fibroblasts. PMID: 24710408
49. The results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China. PMID: 24082858
50. This study reports on the reduction of NOS1 expression in the anterior cingulate cortex in depressive patients. PMID: 22989585

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HGNC: 7872

OMIM: 163731

KEGG: hsa:4842

STRING: 9606.ENSP00000337459

UniGene: Hs.654410