NPC4 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
NPC4 antibody; At3g03530 antibody; T21P5.5 antibody; Non-specific phospholipase C4 antibody; EC 3.1.4.3 antibody
Target Names
NPC4
Uniprot No.
Target Background
Function
NPC4 is a non-specific phospholipase C (PLC) that exhibits significant PLC activity during inorganic phosphate starvation. Its primary substrate is phosphatidylcholine (PC), but it can also hydrolyze phosphatidylethanolamine (PE) with reduced efficiency. Notably, it lacks activity towards phosphatidic acid (PA). NPC4 plays a crucial role in providing both inorganic phosphate and diacylglycerol from membrane-localized phospholipids during phosphate deprivation. It is thought to be essential for the production of lipid-derived signaling molecules that positively modulate abscisic acid (ABA) response, thereby enhancing plant tolerance to drought and salt stresses. Additionally, NPC4 may participate in brassinolide-mediated signaling during root development.
Gene References Into Functions
- Under salt stress conditions, npc4 plants exhibited shorter roots, lower fresh weight, and reduced seed germination. Notably, the expression levels of abscisic acid-related genes, including ABI1, ABI2, RAB18, PP2CA, and SOT12, were significantly reduced in salt-treated npc4 plants. PMID: 21525137
- NPC4 plays a pivotal role in plant response to abscisic acid, drought, and high salinity. PMID: 20699393
- NPC4 is instrumental in supplying both inorganic phosphate and diacylglycerol from membrane-localized phospholipids. PMID: 15618226
Database Links
Protein Families
Bacterial phospholipase C family
Subcellular Location
Cell membrane; Peripheral membrane protein.
Tissue Specificity
Expressed in root tips, cotyledons, on leaf margins, stems, young anthers and funiculus.
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