NPM3 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receipt. Delivery times may vary depending on your location and the purchasing method. For specific delivery timelines, please consult your local distributor.
Synonyms
NPM 3 antibody; NPM3 antibody; NPM3_HUMAN antibody; Nub1 antibody; nucleophosmin/nucleoplasmin family, member 3 antibody; nucleophosmin/nucleoplasmin, 3 antibody; Nucleoplasmin 3 antibody; Nucleoplasmin-3 antibody; PORMIN antibody; RGD1565542 antibody; TMEM123 antibody
Target Names
NPM3
Uniprot No.
Target Background
Function
NPM3 plays a crucial role in regulating diverse cellular processes, including ribosome biogenesis, chromatin remodeling, and protein chaperoning. It modulates the histone chaperone function and RNA-binding activity of nucleolar phosphoprotein B23/NPM. Notably, NPM3 effectively facilitates chromatin remodeling when incorporated into a pentamer complex containing NPM3 and NPM.
Gene References Into Functions
- Research indicates that histone chaperones nucleoplasmin (NPM2/NPM3) exhibit preferential association with histones H2A-H2B in both egg and nuclear autoantigenic sperm protein (NASP) families. PMID: 22968912
- A study characterized the sperm chromatin decondensation and nucleosome assembly activities of homo- and hetero-oligomers of NPM1, NPM2, and NPM3. PMID: 22362753
- NPM3 lacks intrinsic histone chaperone activity but inhibits the histone assembly activity of NPM1 in vitro. Furthermore, it significantly enhances transcription in a cellular system. PMID: 20073534
- Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with the putative histone chaperone NPM3. PMID: 19710011
Database Links
Protein Families
Nucleoplasmin family
Subcellular Location
Nucleus. Nucleus, nucleolus.
Tissue Specificity
Ubiquitous.
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