NREP Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
The antibody is provided as a liquid solution in phosphate-buffered saline (PBS) containing 50% glycerol, 0.5% bovine serum albumin (BSA), and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchasing method and location. For specific delivery details, please consult your local distributor.
Synonyms
3.1 gene antibody; C5orf13 antibody; Chromosome 5 open reading frame 13 antibody; D4S114 antibody; Neuronal protein 3.1 antibody; Neuronal regeneration related protein antibody; Neuronal regeneration related protein homolog (rat) antibody; Neuronal regeneration related protein homolog antibody; NP311_HUMAN antibody; NREP antibody; P311 antibody; PRO1873 antibody; Protein p311 antibody; PTZ17 antibody; SEZ17 antibody
Target Names
NREP
Uniprot No.
Target Background
Function
NREP (Neural Regeneration Protein) is a protein that has been implicated in various cellular processes, including neural function, cell differentiation, and tissue regeneration. Studies have shown that ectopic expression of NREP enhances the motility of gliomas and promotes axonal regeneration. Additionally, NREP is involved in cellular differentiation, such as inducing fibroblast differentiation into myofibroblasts and myofibroblast ameboid migration. It also plays a role in regulating lipid-droplet biogenesis, down-regulating the expression of TGFβ1 and TGFβ2 while not affecting TGFβ3 expression. Further research suggests that NREP may be involved in the regulation of alveolar formation.
Gene References Into Functions
- P311, also known as NREP, acts as a novel regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing, mediated by TGFbeta1/Smad signaling. PMID: 27906099
- P311 (NREP) has been shown to accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cells through activation of RhoA and Rac1. PMID: 27927130
- Research indicates that P311 (NREP) is crucial for the production of normal cutaneous scars. PMID: 27939132
- P311 (NREP) plays a significant role in renal fibrosis via TGFbeta1/Smad signaling, suggesting its potential as a novel target for the management of renal fibrosis. PMID: 26616407
- P311 (NREP) has been shown to promote the migration of ESCs both in mice with superficial partial-thickness burns and in an injured cell model in vitro, indicating its potential role in wound healing. PMID: 22967977
- Protein HYI has been observed to bind closely with protein P311 (NREP) through an alpha helix in hypertrophic scar fibroblasts. PMID: 22490543
- Elevated expression of P311 (NREP) and ITGB4BP has been observed in non-small cell lung cancer, potentially indicating a novel signaling pathway. PMID: 21029697
- P311 (NREP) is potentially involved in the pathogenesis of hypertrophic scar through the induction of myofibroblasts. PMID: 20404911
- Studies suggest a role for P311 (NREP) in inducing TGF-beta1-independent myofibroblast transformation. PMID: 12417574
- Research findings indicate that P311 (NREP) levels play a regulatory role in glioma motility and invasion by influencing the reorganization of the actin cytoskeleton at the cell periphery. PMID: 16229809
- P311 (NREP) expression is tightly controlled during critical periods of alveolar formation, and its absence under pathological conditions may contribute to impaired alveolar regeneration and the development of human emphysema. PMID: 16484684
Subcellular Location
Cytoplasm.
Tissue Specificity
Expressed in lung (at protein level).
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
