NRN1L Antibody

NRN1L Antibody Characteristics

NRN1L antibodies are primarily polyclonal or monoclonal reagents designed for detecting the Neuritin-like protein across species (Human, Mouse, Rat) . Key properties include:

• Host Species: Rabbit (polyclonal) , Mouse (monoclonal) .

• Immunogen: Synthetic peptides or recombinant fragments (e.g., amino acids 39–139 for Bio-Techne’s NBP2-94688) .

• Applications: Western Blot (WB), Immunohistochemistry (IHC), ELISA, and flow cytometry .

• Specificity: Targets epitopes in the middle or C-terminal regions of NRN1L .

Neuronal Development and Disease

• NRN1L antibodies have identified the protein’s role in dendritic spine resilience against amyloid-β (Aβ) in Alzheimer’s disease models, suggesting neuroprotective functions .

• In autoimmune research, monoclonal anti-neuritin antibodies block interactions between neuritin and germinal center B cells, modulating antibody production and allergy responses .

Cancer and Expression Profiling

• The Human Protein Atlas reports NRN1L expression in 20 cancer types, with prognostic associations in survival analyses .

Key Performance Metrics

• Purity: >95% (recombinant protein-based antibodies) .

• Cross-Reactivity: Human, Mouse, Rat .

• Molecular Weight: ~17–18 kDa (varies due to post-translational modifications) .

Functional Insights from Preclinical Studies

• Blocking Activity: Monoclonal antibodies (e.g., clone 27G7) inhibit neuritin binding to B cells, highlighting therapeutic potential in autoimmune disorders .

• Proteomic Integration: NRN1L-induced proteome changes in neurons correlate with synaptic pathways linked to cognitive resilience in Alzheimer’s disease .