NRPB7 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
NRPB7 antibody; RPB19 antibody; At5g59180 antibody; MNC17.9 antibody; DNA-directed RNA polymerase II subunit 7 antibody; RNA polymerase II subunit B7 antibody
Target Names
NRPB7
Uniprot No.
Target Background
Function
DNA-dependent RNA polymerase II catalyzes the transcription of DNA into RNA, utilizing four ribonucleoside triphosphates as substrates. It synthesizes mRNA precursors and numerous functional non-coding RNAs. As a central component of the basal RNA polymerase II transcription machinery, Pol II comprises mobile elements exhibiting relative movement. NRPB7, part of a subcomplex with NRPB4, binds to a pocket formed by NRPB1, NRPB2, and NRPB6 at the base of the clamp element. This NRPB4-NRPB7 subcomplex appears to lock the clamp in a closed conformation via NRPB7, thereby preventing double-stranded DNA entry into the active site cleft. Importantly, the NRPB4-NRPB7 subcomplex exhibits binding affinity for both single-stranded DNA and RNA.
Database Links
Protein Families
Eukaryotic RPB7/RPC8 RNA polymerase subunit family
Subcellular Location
Nucleus.
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