NRPE1 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
NRPE1 antibody; DMS5 antibody; DRD3 antibody; NRPD1b antibody; RMD1 antibody; RPE1 antibody; At2g40030 antibody; T28M21.19 antibody; DNA-directed RNA polymerase V subunit 1 antibody; DNA-directed RNA polymerase D subunit 1b antibody; AtNRPD1b antibody; Nuclear RNA polymerase D 1b antibody; DNA-directed RNA polymerase E subunit 1 antibody; Nuclear RNA polymerase E 1 antibody; EC 2.7.7.6 antibody; Protein DEFECTIVE IN MERISTEM SILENCING 5 antibody; Protein DEFECTIVE IN RNA-DIRECTED DNA METHYLATION 3 antibody; Protein RNA-DIRECTED DNA METHYLATION DEFECTIVE 1 antibody; RNA polymerase IV subunit 1 antibody; POL IV 1 antibody
Target Names
NRPE1
Uniprot No.
Target Background
Function
The NRPE1 antibody targets DNA-dependent RNA polymerase V, the largest and catalytic subunit. This enzyme is crucial for RNA-directed DNA methylation (RdDM)-dependent silencing of endogenous repetitive sequences, including transposable elements. It plays a vital role in both the establishment and the erasure of methylation patterns in response to RNA triggers. Furthermore, NRPE1 is implicated in the synthesis of short interfering RNAs (siRNAs) and is an essential component of a self-reinforcing loop linking de novo DNA methylation to siRNA production and the maintenance of post-transcriptional RNA silencing.
Gene References Into Functions
- Studies suggest that Pol V-dependent de novo methylation, mediated by NRPE1, may regulate the silencing of active protein-coding genes in plants. (PMID: 21771120) PMID: 21771120
- Research investigating mutants deficient in the NRPD1a and NRPD1b subunits of polymerase IV has explored their roles in RNA silencing and the maintenance of transcriptional and post-transcriptional gene silencing. (PMID: 18433438) PMID: 18433438
Database Links
Protein Families
RNA polymerase beta' chain family
Subcellular Location
Nucleus, nucleolus. Note=Clustered within heterochromatic regions and colocalized with RDR2, DCL3, NRPD4, AGO4, and siRNAs within the nucleolus. Recruited to chromatin via its interaction with SUVH2.
Tissue Specificity
Mostly expressed in flowers, and, to a lower extent, in leaves. Present in sperm cells.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
