NUDT7 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
NUDT7 antibody; GFG1 antibody; NUDX7 antibody; At4g12720 antibody; T20K18.70 antibody; Nudix hydrolase 7 antibody; AtNUDT7 antibody; EC 3.6.1.- antibody; ADP-ribose pyrophosphatase antibody; EC 3.6.1.13 antibody; NADH pyrophosphatase antibody; EC 3.6.1.22 antibody; Protein GROWTH FACTOR GENE 1 antibody
Target Names
NUDT7
Uniprot No.
Target Background
Function
NUDT7 is an enzyme that mediates the hydrolysis of certain nucleoside diphosphate derivatives. It exhibits a preference for NADH and ADP-ribose as substrates, but does not hydrolyze 8-oxo-dGTP, cyclic ADP-ribose, GDP-manose, UDP-glucose, ATP, or GTP. Notably, NUDT7 plays a regulatory role in EDS1 signaling, exerting a negative control effect.
Gene References Into Functions
- Research suggests that the active and inactive forms of AtNUDX6 induce the expression of thioredoxin-h5, while the active and inactive forms of AtNUDX7 suppress the accumulation of salicylic acid (SA) and subsequent gene expression. This indicates that AtNUDX6 and AtNUDX7 proteins have distinct roles in stress responses. [AtNUDX7] PMID: 27095738
- Evidence suggests that AtERF1 is crucial for regulating AtNudt7 during oxidative signaling. PMID: 25451743
- AtNUDT7 is essential for maintaining NAD:NADH homeostasis in seeds. PMID: 24504697
- NUDT7 forms complexes in vitro and in vivo with regulatory proteins involved in signal transduction pathways. PMID: 22068106
- AtNUDT7 protein levels increase in response to biotic and abiotic stresses. This protein plays a critical role in maintaining redox homeostasis, particularly in maintaining NADH:NAD+ balance, which is crucial for normal growth and development. PMID: 20704736
- Under oxidative stress, AtNUDX7 functions to maintain NAD(+) levels by supplying ATP through nucleotide recycling from free ADP-Rib molecules. This regulation contributes to the defense mechanisms against oxidative DNA damage by modulating the PAR reaction. [AtNUDX7] PMID: 19656905
- GFG1 is a key gene connecting cellular metabolism and oxidative signaling pathways. PMID: 16328543
- FMO1 and NUDT7 are essential for signaling through an EDS1-dependent but SA-independent branch of plant defense. Importantly, NUDT7 exerts negative control over EDS1 signaling. [NUDT7] PMID: 16531493
- NUDT7 modulates the defense response to prevent excessive stimulation. ADP-ribose and NADH are preferred substrates for this enzyme. PMID: 17660350
- Structure-activity studies have revealed that specific mutations in AtNUDT7 alter its function. Mutations of residues F73 and V168 prevent dimer formation and enzymatic activity. Additionally, mutations of residues V69, F73, and V168 disrupt binding to the regulatory 14-3-3 protein. PMID: 19448856
Database Links
KEGG: ath:AT4G12720
UniGene: At.23449
Protein Families
Nudix hydrolase family
Subcellular Location
Nucleus. Cytoplasm. Cell membrane. Note=Localized at the plasma membrane when in complex with GG2, but present in the cytoplasm when associated with GG1. Detected in the cytoplasm and nucleus when interacting with RACK1A.
Tissue Specificity
Expressed in stems, leaves, roots, flowers and siliques.
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