him-10 Antibody

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Product Specs

Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (made-to-order)
Synonyms
him-10 antibody; R12B2.4 antibody; Kinetochore protein Nuf2 homolog antibody; CeNuf2 antibody; Kinetochore protein him-10 antibody; Protein high incidence of males 10 antibody
Target Names
him-10
Uniprot No.

Target Background

Function
The HIM-10 antibody targets a component of the essential kinetochore-associated NDC80 complex. This complex is crucial for chromosome segregation during both mitosis and meiosis, and is also involved in spindle checkpoint activity. The NDC80 complex works synergistically with the SKA-1 complex to enhance microtubule affinity, potentially enabling the NDC80 complex to track depolymerizing microtubules.
Database Links

KEGG: cel:CELE_R12B2.4

STRING: 6239.R12B2.4

UniGene: Cel.10183

Protein Families
NUF2 family
Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores.

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