odd-1 Antibody

Introduction to OSR1 and Odd-1 Antibody

Odd-1 Antibody refers to immunological reagents targeting Odd-skipped related transcription factor 1 (OSR1), a zinc-finger protein encoded by the OSR1 gene. OSR1 is a homolog of the Drosophila Odd-skipped protein and plays critical roles in embryonic development, including heart formation, intermediate mesoderm differentiation, and organogenesis . The antibody is widely used to detect OSR1 in research settings, enabling studies of its expression patterns, regulatory mechanisms, and pathological implications .

Biological Functions of OSR1

OSR1 is essential for developmental processes:

• Heart Development: OSR1 knockout mice exhibit atrial septal defects, hypoplastic venous valves, and blood backflow, highlighting its role in cardiac morphogenesis .

• Kidney Development: OSR1 is the earliest marker of intermediate mesoderm, the precursor to kidney tissue. It regulates genes like Eya1, Six2, and Pax2, which are critical for nephrogenesis .

• Cancer Regulation: OSR1 acts as a tumor suppressor in lung cancer by inhibiting proliferation and invasion via the Wnt/β-catenin pathway .

Embryonic Development

Cancer Biology

• ↑ GSK3β (inactive)

• ↓ Nuclear β-catenin, cyclin D1, c-Myc . | |

Clinical Implications and Future Directions

OSR1’s dual role in development and disease positions it as a biomarker and therapeutic target. Key areas for future research:

1. Therapeutic Potential: Targeting OSR1 in cancers with dysregulated Wnt signaling (e.g., lung adenocarcinoma).

2. Developmental Disorders: Investigating OSR1 mutations in congenital heart or kidney defects.

3. Antibody Optimization: Developing high-affinity monoclonal antibodies for diagnostic and therapeutic use .