IAR4 Antibody

Clarification of Terminology

The term "IAR4" does not correspond to any recognized antibody, gene, or protein in standard biomedical nomenclature. Possible explanations for this discrepancy include:

• Typographical error: Potential misspellings (e.g., IL4R, FcRH4, or IgG4).

• Obsolete nomenclature: Historical terms no longer in use.

• Proprietary or unpublished identifier: Internal codes from non-public research.

IL4R (Interleukin-4 Receptor) Antibodies

• Function: Target the IL-4 receptor alpha (IL-4Rα) subunit, critical for Th2 immune responses.

• Mechanism: Block IL-4/IL-13 signaling to reduce inflammation in allergies and asthma .

• Examples:

  Antibody Name	Target	Clinical Use
  Rademikibart (CBP-201)	IL-4Rα	Atopic dermatitis, asthma
  Dupilumab	IL-4Rα	Eczema, chronic rhinosinusitis

FcRH4 (Fc Receptor Homolog 4) Antibodies

• Role: Inhibits B cell receptor (BCR) signaling and marks memory B cells .

• Applications: Studied in autoimmune disorders and lymphoid malignancies .

IgG4 Antibodies

• Characteristics:

  • Induced by repeated antigen exposure (e.g., mRNA vaccines) .

  • Implicated in immune tolerance and cancer progression .

Research Gaps and Recommendations

• Validation of "IAR4": Confirm the term’s accuracy through direct communication with the query source.

• Alternative Searches: Explore antibodies targeting IL-4Rα, FcRH4, or IgG4, which are well-documented in immunology.

IL-4Rα Antibodies (e.g., Rademikibart)

• Potency: IC₅₀ of 7.0 ng/mL for IL-4-mediated STAT6 inhibition .

• Species Specificity: Binds human IL-4Rα exclusively .

IgG4 in Disease

• Pathogenic Role: Elevated IgG4 linked to immune tolerance in cancer and autoimmune disorders .

• Functional Impact: Reduces FcγR-mediated phagocytosis and cytotoxicity .