OIP5 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery times may vary depending on the purchasing method or location. Please consult your local distributor for specific delivery time information.
Synonyms
OIP5 antibody; MIS18B antibody; Protein Mis18-beta antibody; Cancer/testis antigen 86 antibody; CT86 antibody; Opa-interacting protein 5 antibody; OIP-5 antibody
Target Names
OIP5
Uniprot No.
Target Background
Function
OIP5 Antibody is essential for the recruitment of CENPA to centromeres and the proper segregation of chromosomes during mitosis.
Gene References Into Functions
- LncRNA OIP5-AS1 suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC cells by regulating DYRK1A expression through miR-369-3p. PMID: 29773344
- LncRNA OIP5-AS1 modulated the expression of Bcl-2 by targeting miR-448 in lung adenocarcinoma cells. PMID: 29247949
- The OIP5-AS1 interaction network might function as an oncogene in bladder cancer progression. PMID: 28843748
- Research indicates that CDK1 controls Mis18 complex recruitment to centromeres by regulating oligomerization of M18BP1 through the Mis18alpha:Mis18beta scaffold. PMID: 28059702
- Elevated OIP5 expression is associated with bladder cancer. PMID: 28752236
- Mitofusin 2 knockdown altered Neisseria gonorrhoeae opacity-associated-interacting protein 5 (OIP5) expression. PMID: 29034772
- Findings suggest that OIP5 may be involved in hepatocellular carcinoma (HCC) growth and metastasis, and that miR-15b-5p inhibits OIP5-mediated oncogenic signaling in HCC. PMID: 28184024
- The Mis18 complex contains dual CENP-C recognition motifs that are combinatorially required to generate robust centromeric localization leading to CENP-A deposition. PMID: 27239045
- OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. PMID: 27916718
- Stable binding of Mis18alpha-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A deposition. PMID: 26942680
- Over-expression of OIP5 was observed in breast tumors. PMID: 26107214
- Mis18beta binds with and specifies the centromere localization of HJURP. PMID: 24519934
- Research has shown that betaTrCP-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of the Mis18 complex from late mitosis to early G1 phase. PMID: 24269809
- Expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner. PMID: 23292864
- OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients. PMID: 22129094
- These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells. PMID: 20510019
- Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere, have been identified. [Mis18alpha, Mis18beta, M18BP1] PMID: 17199038
Database Links
Protein Families
Mis18 family
Subcellular Location
Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
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