osta-3 Antibody

Applications and Validation

Validated for Western Blot (WB) and ELISA:

Key Performance Data:

• Detects endogenous OSTA in small intestine tissues, critical for studying bile acid transport .

• Specificity confirmed via immunoblotting with minimal cross-reactivity .

Biological Role of OSTA (SLC51A)

OSTA forms a heterodimer with OSTB to mediate cellular uptake of bile acids, steroids, and other organic solutes. Dysregulation is linked to metabolic disorders and cholestasis.

Functional Domains:

• Transmembrane domains: Facilitate solute transport across membranes.

• Extracellular loops: Potential sites for ligand interaction .

Comparative Analysis with Related Antibodies

While OSTA-3 Antibody (31330-1-AP) is specific to SLC51A, other antibodies in oncology (e.g., anti-HER2 OST-HER2 or anti-LAG-3 antibodies ) target distinct pathways.

Research Limitations and Future Directions

• Current Gaps: Limited in vivo data on OSTA antibody therapeutic potential.

• Opportunities:

  • Mechanistic studies on OSTA/OSTB interaction in disease models.

  • Expansion into immunohistochemistry (IHC) or flow cytometry applications.