PP2C27 Antibody
Description
Identified Terminology Ambiguity
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No studies or commercial products referencing a "PP2C27 Antibody" were identified in the provided sources or indexed literature.
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The numeral "27" in PP2C27 likely denotes a specific isoform within the PP2C family, but no associated antibodies are documented.
Potential Misinterpretation of Similar Terms
The search results highlight antibodies targeting PP2Ac (Protein Phosphatase 2A catalytic subunit), a related but distinct enzyme. For example:
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Phospho-Tyr307 PP2Ac Antibodies: Widely used in cancer research, but these reagents face validation challenges. Studies show antibodies like E155 and F-8 cannot differentiate phosphorylated vs. unmodified PP2Ac, leading to unreliable data (Source 7).
| Antibody | Target Site | Key Issue |
|---|---|---|
| E155 (Abcam) | PP2Ac Tyr307 | Binds unphosphorylated PP2Ac |
| F-8 (Santa Cruz) | PP2Ac Tyr307 | Detects Thr304 phosphorylation artifacts |
| R&D Systems Polyclonal | PP2Ac Tyr307 | Sensitivity to Leu309 methylation |
Recommendations for Clarification
To resolve ambiguity:
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Verify the compound name: Confirm if "PP2C27 Antibody" refers to PP2Ac, PP2C isoforms (e.g., PP2Cα), or a novel target.
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Explore analogous systems: For PP2C family antibodies, refer to studies on PP2Cα or PP2Cβ, which are better characterized.
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Validate commercial sources: Cross-check reagent databases (e.g., CiteAb, Antibodypedia) for unindexed antibodies.
Gaps in Current Knowledge
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Structural Data: PP2C27’s crystal structure and epitope accessibility remain unstudied, hindering antibody development.
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Functional Studies: No in vivo or in vitro data on PP2C27-specific antibodies exist.
