P2RX1 Antibody

1. Healthy human eosinophils express functional P2X1 receptors, whose activation leads to eosinophil alphaMbeta2 integrin-dependent adhesion. P2X1 responses are consistently reduced in asthmatic eosinophils compared to healthy ones, likely due to an increase in extracellular nucleotide concentration. PMID: 27183585
2. The expression of P2X1 transcript and its splicing variant P2X1del is observed in most human monocytes. PMID: 27823931
3. Evidence suggests that vascular smooth muscle cells from human gastro-omental arteries express P2X1 and P2X4 receptor subunits. PMID: 24845338
4. P2X1 receptor activation enhances platelet activation evoked by mild stimulants via the p38 signaling pathway. PMID: 24633352
5. Research indicates that adenine nucleotides acting at P2X1 receptors inhibit the proliferation of human coronary smooth muscle cells through the induction of the early gene NR4A1. PMID: 23873636
6. With the development of leukemia, the expression of P2X7R increases in both bone marrow and spleen macrophages, while P2X1 receptor expression increases in spleen macrophages. PMID: 24661878
7. Elevated P2X1 receptor expression and ATP release may contribute to the augmentation of contractile response induced by hypoxia-glucopenia and reoxygenation in the detrusor muscles. PMID: 23975903
8. Studies indicate that MgATP2- activates P2X1 and P2X3, but not P2X2 and P2X4 receptors. PMID: 23959888
9. Research has shed light on the contribution of the extracellular, transmembrane, and intracellular segments to recovery from desensitization. PMID: 23740251
10. P2X(1) ion channels play a protective role in endotoxemia by negatively regulating systemic neutrophil activation, thereby limiting the oxidative response, coagulation, and organ damage. PMID: 22212928
11. Findings suggest that conformational change in the P2X1 receptor is required for the coordinated action of ATP. PMID: 22971236
12. HSP90 inhibitors may be as effective as selective antagonists in regulating platelet P2X1 receptors. Their potential effects on hemostasis should be considered in clinical studies. PMID: 22851178
13. Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel. PMID: 22393010
14. Studies indicate that P2X1, P2X2, and P2X4 receptors are detected in preglomerular microvessels. PMID: 21768526
15. The cytoskeleton plays a crucial role in P2X1 receptor regulation. PMID: 21757694
16. Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating. PMID: 21690089
17. T-cell receptor stimulation results in the translocation of P2X1 and P2X4 receptors and pannexin-1 hemichannels to the immune synapse. PMID: 20660288
18. PMA-evoked Ca(2+) entry results from an NCX3-dependent dense granule secretion and subsequent P(2X1) receptor activation by secreted ATP, rather than activation of a novel NCCE pathway. PMID: 20345709
19. Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP. PMID: 20699225
20. These studies demonstrate, for the first time, a significant role of receptor recycling in P2X1 receptor responsiveness. PMID: 20374431
21. TLR2/1 agonist-induced platelet aggregation and secretion depend on P2X1-mediated Ca2+ mobilization, production of TxA2, and ADP receptor activation. PMID: 20024498
22. Research indicates that the release of ATP and subsequent activation of P2 receptors help establish the basal level of activation for signal transduction pathways and regulate a wide array of responses. PMID: 20068232
23. P2X(1) receptors exhibit an anti-inflammatory effect, reducing NF-kappaB activation and TNF-alpha release. PMID: 20110693
24. Expression of the P2X1 receptor is reduced in type 2 diabetes, not due to alterations in receptor distribution and mRNA expression, but potentially due to differences in receptor sensitivity. PMID: 19808895
25. Data confirmed the presence of functional P2X1, P2X4, and P2X7 receptors in LAD2 cells and HLMCs. PMID: 19552691
26. Ionotropic P2X1 receptors may play a priming role in the subsequent activation of metabotropic P2Y receptors during platelet stimulation. PMID: 11815371
27. The P2X1 ion channel acts as a positive regulator of platelet responses to collagen. PMID: 11816716
28. Research has illuminated the role of tyrosine residues that are essential for the function of the P2X1 receptor. PMID: 12135734
29. P2X1 receptor activation mediates the activation of extracellular signal-regulated kinase 2 (ERK2) and contributes to platelet secretion and aggregation induced by collagen. PMID: 12239162
30. Early, transient Ca2+ influx via P2X1 receptors can contribute to platelet activation by stimulating a significant morphological change, but does not readily synergize with P2Y12 receptors to support aggregation. PMID: 12353081
31. P2X1 plays a role in hemostasis and thrombosis through its involvement in collagen-, thromboxane A(2)-, and shear stress-triggered platelet responses. PMID: 12521992
32. Decreased expression of the contractile P2X1 receptor could lead to reduced vascular tonus and increased blood flow. PMID: 12791671
33. ATP is the primary physiological agonist at P2X1 receptors and plays a role in the activation of platelets. PMID: 12907444
34. The P2X1-ERK2-Myosin Light Chain Kinase axis contributes to collagen-induced platelet activation by enhancing platelet degranulation. PMID: 14500714
35. Detrusor nerve varicosities from sensory urgency patients revealed a general loss of all presynaptic P2X subtypes, with the proportion containing receptors reducing to only 0.5-5% depending on the P2X subtype. PMID: 14557870
36. P2X1 stimulation can induce or potentiate platelet activation in combination with other platelet agonists. PMID: 14675100
37. Residues Lys-68, Phe-185, Phe-291, Arg-292, and Lys-309 contribute to ligand binding at P2X(1) receptors, with Phe-185 and Phe-291 coordinating the binding of the adenine ring of ATP. PMID: 14699168
38. The P2X(1) ion channel induces MLC-mediated cytoskeletal rearrangements, thus contributing to SIPA and degranulation during VWF-triggered platelet activation. PMID: 15087444
39. P2X1 receptors are expressed in human cardiomyocytes and primarily distributed in the regions of intercalated discs. There is some close association of P2X1 receptors and connexin43 in some, but not all, regions. PMID: 15686781
40. Results suggest that lipid rafts play a significant role in P2X1 receptor-mediated control of arteries. PMID: 16006561
41. P2X1 receptors play a role in the early collagen-evoked intracellular Ca2+ responses of human platelets. PMID: 16113781
42. Glycine 250 substitution by serine produced functional responses to ATP with no effect on ATP sensitivity, but a reduction in peak amplitude to P2X1 receptors. PMID: 16236030
43. P2X receptor-mediated contractions of the human pregnant uterus to alpha,beta-meATP and EFS, but not to ATP, are increased with the progression of pregnancy. PMID: 16359770
44. Both P2X(1) and ERK2 participate in shear stress-controlled thrombosis, but ERK2 activation is initiated predominantly via GPIb-VWF interactions. PMID: 16420578
45. Researchers have identified and characterized the P2X1 promoter utilized in MEG-01 cells. Binding of Sp1/3 and NF-1 to elements in the direct vicinity of the transcription start site is essential for basal transcription. PMID: 16529657
46. Studies indicate that lipid rafts play a significant role in the regulation of P2X1, but not P2Y1 receptors, in human platelets. Additionally, a reserve of non-functional P2X1 receptors may exist. PMID: 16546137
47. Analysis of a novel interaction between platelet P2X1 and thrombin receptors reveals that P2X1 functions to amplify aggregation responses at low levels of thrombin receptor stimulation. PMID: 16634759
48. Co-expression of T18A and K367A mutant P2X1 receptors produced larger ATP-evoked responses than either mutant alone, suggesting that these amino and carboxy terminal regions interact to regulate channel function. PMID: 16997281
49. Increased P2X1 mRNA expression may occur as a consequence of an increased component of neural ATP release in the aging bladder. PMID: 17399929
50. In PAR4-pretreated platelets, epinephrine caused dense granule secretion. Subsequent signaling from the ATP-gated P2X(1)-receptor and the alpha(2A)-adrenergic receptor induced aggregation. PMID: 18480058

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HGNC: 8533

OMIM: 600845

KEGG: hsa:5023

STRING: 9606.ENSP00000225538

UniGene: Hs.41735