dpy-18 Antibody
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
dpy-18 antibody; phy-1 antibody; Y47D3B.10Prolyl 4-hydroxylase subunit alpha-1 antibody; 4-PH alpha-1 antibody; EC 1.14.11.2 antibody; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 antibody; Protein dumpy-18 antibody
Target Names
dpy-18
Uniprot No.
Target Background
Function
This antibody catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences within collagens and other proteins.
Gene References Into Functions
- Research indicates that DPY-18 regulates ephrin expression to direct axon guidance, suggesting a conserved role for P4Hs in higher organisms. PMID: 25471573
- While collagen P4Hs, PHY-1/PHY-2/(PDI)(2) mixed tetramer and PHY/PDI dimers, do not exhibit processive activity on peptide substrates, inhibiting hydroxylation at one catalytic site within the tetramer hinders the function of the other catalytic site. PMID: 14985345
Database Links
Protein Families
P4HA family
Subcellular Location
Endoplasmic reticulum lumen.
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