Function
The phosphorylation of phosphatidylinositol (PI) to PI4P constitutes the initial committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 serves as a precursor for the second messenger inositol 1,4,5-trisphosphate (InsP3). This kinase exhibits autophosphorylation activity and phosphorylates serine/threonine residues within protein substrates. In vitro, it has been demonstrated to phosphorylate RPN10 and UFD1.