PAE2 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
PAE2 antibody; At1g57590 antibody; T8L23.6 antibody; Pectin acetylesterase 2 antibody; EC 3.1.1.- antibody
Target Names
PAE2
Uniprot No.
Target Background
Function
This antibody hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell walls, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Reducing the degree of acetylation of pectin gels in vitro alters their physical properties.
Database Links
Protein Families
Pectinacetylesterase family
Subcellular Location
Secreted, cell wall.
Q&A
Here’s a structured FAQ for researchers investigating PAR2 antibodies in academic contexts, synthesized from peer-reviewed studies and optimized for methodological depth:
Advanced Research Questions
How to resolve contradictory PAR2 activation phenotypes across studies?
What strategies improve PAR2 antibody translational potential despite low oral bioavailability?
-
Local delivery: Intranasal or intra-articular administration (tested in arthritis models) to bypass systemic exposure limitations .
-
Bispecific designs: Combine PAR2 inhibition with VEGF/TNF-α blockers to target multi-pathway diseases (e.g., atherosclerosis) .
How to validate PAR2 antibody binding modes and allosteric effects?
-
Molecular docking: Predict binding pockets (e.g., PAR2 antagonist AZ8838 binds a site distinct from the tethered ligand domain) .
-
Cryo-EM/XR: Resolve antibody-PAR2 complexes to guide affinity maturation (e.g., Fab3949 blocks ligand-receptor engagement) .
Data Analysis & Interpretation
What metrics define PAR2 antibody efficacy in migraine models?
Key Methodological Recommendations
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
