PAK2 (Ab-197) Antibody

1. Overexpression of PAK2 in oral squamous cell carcinomas may be associated with an advanced pathology grade. PMID: 29714078
2. The promotion of apoptosis by human cytomegalovirusmiRUS45p in cells was specifically mediated via inhibition of PAK2 expression. PMID: 28765936
3. Leukemic cells explicitly require PAK2 for growth towards an extracellular matrix. PAK2-deficient cells fail to form colonies in methylcellulose and induce lymphomas in vivo. Consequently, PAK2 may be the critical isoform in leukemic cells, controlling tumor growth. PMID: 28707321
4. Research indicates that PAK2 kinase plays an alternative anti-apoptotic role, phosphorylating caspase-7 and promoting unfettered cell growth and chemotherapeutic resistance. PMID: 27889207
5. Overexpression of miR-137 was found to inhibit the proliferation of melanoma cells, a phenomenon that could be replicated by PAK2 knockdown using siRNAs. PMID: 26186482
6. PAK2 is a direct effector of TSC1-TSC2-RHEB signaling and a potential target for rational drug therapy in TSC. PMID: 26412398
7. Nef exploits PAK2 in a stepwise mechanism where its kinase activity collaborates with an adaptor function for the exocyst complex to inhibit host cell actin dynamics. PMID: 26350970
8. Cytoplasmic Pak2 may promote cell proliferation in normal endometrium during the menstrual cycle. PMID: 26218748
9. Further analyses show that HDAC6 may promote growth of GBM cells through inhibition of SMAD2 phosphorylation, subsequently downregulating p21. PMID: 26150340
10. Findings suggest that repression of microRNA miR-134 and consequent up-regulation of p21-activated kinase 2 (Pak2) might contribute to paclitaxel resistance. PMID: 26363097
11. Inhibition of PAK activation at late G2-phase centrosomes, caused by Rac1 inactivation, coincides with impeded activation of Aurora A and the CyclinB/Cdk1 complex, resulting in delayed mitotic entry. PMID: 24840740
12. Research has identified Pak2 as a potentially important mediator of ovarian cancer cell migration on extracellular matrix. PMID: 25050916
13. PAK2 activation may be linked to advanced tumor progression and a poor prognosis in gastric cancer. PMID: 24621074
14. Prostasin represses cancer cells and contributes to chemoresistance by modulating the CASP/PAK2-p34/actin pathway. PMID: 24434518
15. Studies demonstrate that HIV-1 Nef expression mediates phosphorylation of Mek1 on serine298 and Pak2 on serine192/197 in T cell lines as well as primary human T cells. PMID: 23746211
16. Thrombin induces monocyte/macrophage migration via PAR1-Galpha12-dependent Pyk2-mediated Gab1 and p115 RhoGEF interactions, leading to Rac1- and RhoA-targeted Pak2 activation. PMID: 24025335
17. PAK2 negatively modulates TGF-beta signaling by attenuating the receptor-Smad interaction and subsequent Smad activation. PMID: 22393057
18. Low-to-moderate penetrance protein coding mutations or non-coding mutations at DLG1 and/or PAK2, or a nearby gene, may reproduce the behavioral characteristics of the 3q29 microdeletion. PMID: 21850710
19. The ability of Nef to associate with PAK2 correlates with the ability to enhance HIV-1 replication. PMID: 21819585
20. High PAK2 expression mediates chemotherapeutic resistance in human breast invasive ductal carcinoma by negatively regulating caspase-7 activity. PMID: 21555521
21. High PAK2 is associated with melanoma. PMID: 21177766
22. Mechanistic studies on the autoactivation of PAK2 suggest a two-step model of cis initiation followed by trans amplification. PMID: 21098037
23. Analysis has identified evolutionary conserved residues crucial for the catalytic activity of PKA and Pak2. PMID: 20209159
24. The association between the CD4 receptor and protein kinase pp58 and the protein-tyrosine kinase within the cell introduces a specific pathway by which T lymphocytes become activated. PMID: 20724730
25. MYO18A is a novel binding partner of the PAK2/betaPIX/GIT1 complex, suggesting that MYO18A may play a significant role in regulating epithelial cell migration by influencing multiple cellular machineries. PMID: 19923322
26. Knockdown of PAK2 enhances the loss of cell-cell junctions and increases lamellipodium extension, but does not affect migration speed in Hepatocyte Growth Factor (HGF) stimulated DU145 prostate carcinoma cells. PMID: 19628037
27. The enzymatic phosphorylation reaction of PAK2 can be best interpreted by a rapid-equilibrium random bi-bi reaction model; the catalysis reaction is partially limited by both the phosphoryl group transfer and the product release steps. PMID: 12549935
28. The opposing effects of Core protein on the transcription of P21 might be important in the progression of liver disease in HCV-positive patients. PMID: 12823590
29. Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation. PMID: 12853446
30. Studies have identified sites of PAK2 autophosphorylation in the regulatory and catalytic domains, along with their kinetic effects. Multiple regions of PAK2 are involved in enzyme-substrate recognition. PMID: 12907671
31. Pak2 phosphorylates Myc at three sites (T358, S373, and T400), influencing Myc functions both in vitro and in vivo. PMID: 14749374
32. Nef induces signal transduction through the recruitment of a signaling machinery, including Pak2, into lipid rafts, mimicking a physiological cellular mechanism to initiate the TCR cascade. PMID: 15047825
33. PAK2 kinase activity increases in response to TCR stimulation, suggesting a novel role for PAK2 as a positive regulator of T cell activation. PMID: 15187108
34. PAK2 interacts with Nef proteins from SIV-infected chimpanzees. PMID: 15194762
35. Pak2 plays a role in the down-regulation of translation initiation during apoptosis by phosphorylation of Mnk1. PMID: 15234964
36. PS-GAP is a novel regulator of caspase-activated PAK-2. PMID: 15471851
37. PAK-2 is activated in 1-LN prostate cancer cells by a proteinase inhibitor, alpha 2-macroglobulin. PMID: 15908432
38. Binding of Cdc42 localizes Pak2 to the endoplasmic reticulum, where autophosphorylation alters the association of the two proteins. PMID: 16204230
39. Pak2 binds to and phosphorylates initiation factor eIF4G, inhibiting the association of eIF4E with m7GTP, reducing translation initiation. PMID: 16281055
40. Nef protein amino acids at positions 85, 89, 187, 188, and 191 (L, H, S, R, and F in the clade B consensus, respectively) are crucial for Pak2 association and activation. PMID: 16501114
41. Posttranslational myristoylation of PAK2 might be part of a unique series of mechanisms involved in regulating the later events of apoptosis. PMID: 16617111
42. c-Abl represents a target downstream of phosphatidylinositol 3-kinase-activated PAK2, which differentiates TGF-beta signaling in fibroblasts and epithelial cell lines. PMID: 16867995
43. This study of tissue-derived HIV-1 Nefs demonstrates that CD4 and MHC-I downregulation are highly conserved Nef functions, while Pak2 association is variable in late-stage AIDS patients. PMID: 16979207
44. Studies have defined a new class of PAK-interacting proteins, which play a crucial role in actin cytoskeletal reorganization. PMID: 17543336
45. Interaction of Nef with PAK2 does not play a major role in T-cell activation, viral replication, and apoptosis. PMID: 17881449
46. Protein phosphatase 1alpha can act directly on phosphorylated Thr-402 in the activation loop of PAK2 and down-regulate its kinase activity. PMID: 18176785
47. Data show that RNAi-mediated or dominant-negative suppression of Pak2, major regulators of cytoskeletal signaling downstream of Cdc42 or Rac1, markedly inhibits EC lumen and tube formation. PMID: 18319301
48. Huntingtin exerts anti-apoptotic effects by binding to Pak2, reducing the abilities of caspase-3 and caspase-8 to cleave Pak2 and convert it into a mediator of cell death. PMID: 19240112
49. PAK-2 activity controls the apoptotic response by regulating levels of activated caspase 3 and thereby its own cleavage to the proapoptotic PAK-2p34 fragment. PMID: 19242610

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HGNC: 8591

OMIM: 605022

KEGG: hsa:5062

STRING: 9606.ENSP00000314067

UniGene: Hs.518530