PANS1 Antibody
Product Specs
Target Background
This antibody targets PANS1, a protein crucial for maintaining centromeric cohesion during interkinesis (the interphase between meiosis I and meiosis II) and ensuring proper sister chromatid segregation in meiosis II. Its role extends to centromere cohesion during meiosis I, spindle organization at the end of telophase I and in meiosis II, and prevention of premature pericentromeric cohesin release during meiosis. Importantly, PANS1 is not required for initial cohesion establishment or monopolar kinetochore orientation in meiosis I. Beyond meiosis, PANS1 plays a significant role in somatic development, regulating mitotic cell division and maintaining ploidy stability in somatic cells. Evidence suggests involvement in microtubule dynamics, tolerance to abiotic stresses and mono/divalent ions, and the maintenance of meristematic activity under saline conditions. Furthermore, PANS1, along with GIG1, functions within a network linking centromere cohesion and cell cycle progression by modulating Anaphase-Promoting Complex/Cyclosome (APC/C) activity. Specifically, PANS1 regulates the number of dividing cells in the root meristem and is essential for controlling anaphase onset via an APC/C-mediated pathway. Finally, it contributes to maintaining proper chromosome arm cohesion under stressful conditions.
- CMR1/PANS1 likely coordinates mitotic cell cycle progression by inhibiting the anaphase-promoting complex/cyclosome (APC/C), playing a vital role in stress adaptation. PMID: 26261921
- Primarily expressed during meiosis I, PANS1 performs a critical function; PANS1 and OSD1 are part of a network connecting centromere cohesion and cell cycle progression through APC/C activity regulation. PMID: 26272661
- PANS1 maintains ploidy stability during both meiosis and mitosis. PMID: 24506176
