PBRP1 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
PBRP1 antibody; PBRP antibody; At4g36650 antibody; C7A10.710 antibody; Plant-specific TFIIB-related protein 1 antibody; Plant-specific TFIIB-related protein antibody; AtPBRP antibody; TFIIB-related protein PBRP1 antibody
Target Names
PBRP1
Uniprot No.
Target Background
Function
PBRP1 is a plant-specific TFIIB-related protein that may participate in an intracellular signaling pathway between plastids and the nucleus. It is thought to function as a general transcription factor (GTF) in RNA polymerase I-dependent transcription and rRNA synthesis. PBRP1 forms a ternary complex with TBP2 and the rDNA promoter region.
Database Links
Subcellular Location
Plastid, chloroplast outer membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Tissue Specificity
Widely expressed.
Q&A
FAQs for PBRP1 Antibody Research
Advanced Research Questions
What genetic factors influence host immune recognition of PBRP1 epitopes?
No association was found between HLA-DRB1*/DQB1* alleles and antibody responses to PvRMC-RBP1 in malaria-exposed cohorts .
-
Key finding: 52.9% of individuals lacked detectable antibodies, suggesting non-HLA genetic or environmental factors .
-
Method: Perform PCR-SSO typing for HLA alleles and correlate with IgG reactivity indices .
How can antibody developability challenges be addressed during therapeutic development?
-
Computational prediction: Use tools like the IEDB population coverage calculator to prioritize epitopes with broad HLA compatibility .
-
High-throughput screening: Assess aggregation propensity and solubility early using low-concentration assays (e.g., PEG-induced precipitation) .
What mechanisms underlie reduced antibody production in PBRP1-deficient models?
Ptbp1 deficiency disrupts RNA splicing required for:
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
