PCOLCE Antibody, HRP conjugated

This antibody targets PCOLCE, which binds to the C-terminal propeptide of type I procollagen, thereby enhancing procollagen C-proteinase activity. The C-terminal processed portion of PCPE (CT-PCPE) may exhibit metalloproteinase inhibitory activity.

PCOLCE Function and Clinical Significance: Research indicates PCOLCE plays a multifaceted role, influencing various biological processes. Key findings include:

• Liver Fibrosis: Serum PCPE-1 levels may serve as a non-invasive biomarker for liver fibrosis in chronic hepatitis B (PMID: 29683980).
• Collagen Fibril Assembly: PCPE-1 interaction with syndecans and/or fibronectin appears to regulate collagen fibril assembly on the cell surface (PMID: 25286301).
• Tumor Growth & Other Processes: Analysis of the PCPE-1 interaction network suggests involvement in tumor growth, neurodegenerative diseases, and angiogenesis (PMID: 24117177).
• Muscle Fibrosis: Nuclear retention and extracellular depletion of PCOLCE are implicated in late-onset muscle fibrosis (PMID: 23815790).
• Collagen Maturation: Procollagen C-proteinase enhancer facilitates collagen precursor maturation by binding to the C-propeptide trimer (PMID: 23550162).
• Bone Disease Diagnosis: Combined data on PCPE concentration and isoforms may prove valuable in the diagnosis and monitoring of bone diseases (PMID: 21569766).
• Procollagen Processing: Procollagen C-proteinase enhancer specifically stimulates procollagen processing via C-propeptide binding (PMID: 21940633).
• Cell Interaction: PCPE-1 interacts with heparin/heparan sulfate and plays a role in cell interactions (PMID: 20729553).
• Metalloproteinase Activity: The netrin-like domain of PCPE-1 influences metalloproteinase activity (PMID: 20207734).
• BMP-1 Activity: The CUB1 and CUB2 domains are essential for enhancing BMP-1 activity and binding to a mini-procollagen substrate (PMID: 19801683).
• Procollagen Cleavage: PCPE binds to sites flanking the procollagen cleavage site, assisting procollagen C-proteinases (PMID: 12105202).
• Collagen Binding & Competition: PCPE1 and PCPE2 exhibit collagen-binding capabilities and compete with procollagen C-proteinases for binding sites (PMID: 12393877).
• Molecular Structure: Procollagen C-proteinase enhancer is a multidomain glycoprotein with an elongated structure (PMID: 12486138).
• NTR Domain Structure: The three-dimensional structure of the NTR domain of human PCOLCE1 is characterized (PMID: 12670942).
• BMP1 Enhancement: PCPE-1 does not enhance chordinase activity of BMP1 (PMID: 15817489).
• Tolloid-like 1 Interaction: Tolloid-like 1 interacts with PCPE-1, exhibiting functional differences from BMP-1 (PMID: 16507574).
• Calcium Binding: PCPE-stimulating activity depends on a calcium-binding motif in the CUB1 domain (PMID: 17446170).
• Bone Metabolism: PCPE is among proteins linked to bone/cartilage metabolism in bone fracture patients (PMID: 17602227).
• Beta2-microglobulin Interaction: PCPE-1 interacts with beta2-microglobulin, potentially initiating amyloid fibril formation (PMID: 18164932).
• Procollagen I mRNA Expression: Procollagen I mRNA expression is decreased in synovial fluid from patients with prosthesis loosening (PMID: 18350290).
• Bone Physiology & Pathology: The sPCPE1 glycopattern is associated with the physiological and pathological states of bone (PMID: 19361460).

HGNC: 8738

OMIM: 600270

KEGG: hsa:5118

STRING: 9606.ENSP00000223061

UniGene: Hs.202097